Reactome | ALOX12 oxidises LTA4 to LXA4

Schema > Reaction > Entries

ALOX12 oxidises LTA4 to LXA4 Show undefined attributes

catalystActivity	[CatalystActivity:10387012] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX12:Fe2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10387014
displayName	ALOX12 oxidises LTA4 to LXA4
eventOf	[Pathway:R-BTA-2142700] Biosynthesis of Lipoxins (LX) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-2161779] LXA4 is oxidised to 15k-LXA4 by HPGD - Bos taurus
inferredFrom	[Reaction:R-HSA-2161775] ALOX12 oxidises LTA4 to LXA4 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 2 × [SimpleEntity:R-ALL-9032038] LTA4 [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALOX12 oxidises LTA4 to LXA4 2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin A4
output	2 × [SimpleEntity:R-ALL-2161759] LXA4 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2161775
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2142700] Biosynthesis of Lipoxins (LX)
(precedingEvent)	[Reaction:R-BTA-2161779] LXA4 is oxidised to 15k-LXA4 by HPGD
(inferredTo)	[Reaction:R-HSA-2161775] ALOX12 oxidises LTA4 to LXA4

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