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Entries
MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine
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authored
[InstanceEdit:2162171] D'Eustachio, P, 2012-03-14
catalystActivity
[CatalystActivity:2161186] N6-methyl-AMP deaminase activity of MAPDA:Zn [cytosol]
catalystActivityReference
[CatalystActivityReference:9643765] N6-mAMP deaminase activity of ADAL:Zn [cytosol] Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:2161188] D'Eustachio, P, 2012-03-08
crossReference
[DatabaseIdentifier:12668037] RHEA:16002
dbId
2161187
displayName
MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine
edited
[InstanceEdit:2162250] D'Eustachio, P, 2012-03-16
eventOf
[Pathway:R-HSA-74217] Purine salvage - Homo sapiens
input
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-9731626] N(6)-methyl-AMP(2-) [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2161091] Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates
[LiteratureReference:9731608] MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine
N6-methyl-AMP(2-) + H2O + H+ => IMP(2-) + methylamine
Deamination of N6-methyl-AMP to form IMP
orthologousEvent
[Reaction:R-MMU-2161187] MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine - Mus musculus
[Reaction:R-CEL-2161187] MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine - Caenorhabditis elegans
[Reaction:R-DME-2161187] MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine - Drosophila melanogaster
[Reaction:R-GGA-2161187] MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine - Gallus gallus
[Reaction:R-XTR-2161187] MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine - Xenopus tropicalis
[Reaction:R-DRE-2161187] MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine - Danio rerio
[Reaction:R-SSC-2161187] MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine - Sus scrofa
[Reaction:R-BTA-2161187] MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine - Bos taurus
[Reaction:R-CFA-2161187] MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine - Canis familiaris
output
[SimpleEntity:R-ALL-29602] IMP [cytosol]
[SimpleEntity:R-ALL-9731652] methylamine [cytosol]
precedingEvent
[Reaction:R-HSA-9731632] NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP - Homo sapiens
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2162241] Jassal, B, 2012-03-16
revised
[InstanceEdit:9731633] D'Eustachio, Peter, 2021-05-21
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2161187
summation
[Summation:2161192] Cytosolic MAPDA (N6-Methyl-AMP deaminase) (also known as ADA...
updateTrackers
[UpdateTracker:9775802] Update Tracker - [Reaction:2161187] ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine - v78:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9984674] Update Tracker - [Reaction:2161187] ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine - v96:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9775802] Update Tracker - [Reaction:2161187] ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine - v78:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9984674] Update Tracker - [Reaction:2161187] ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine - v96:[modifyText]
(hasEvent)
[Pathway:R-HSA-74217] Purine salvage
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