ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine

Stable Identifier
R-HSA-2161187
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
N6-methyl-AMP(2-) + H2O + H+ => IMP(2-) + methylamine, Deamination of N6-methyl-AMP to form IMP
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of N6-methyl-AMP and water to form IMP and methylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011). Scaletti et al. (2021) suggest that under physiological conditions this reaction could enable the detoxification and salvage of methylated adenosine nucleotides.

Literature References
PubMed ID Title Journal Year
32144205 MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

Vallin, KS, Jemth, AS, Scaletti, ER, Stenmark, P, Helleday, T, Sarno, A, Warpman Berglund, U, Bräutigam, L

J Biol Chem 2020
21755941 Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates

Furman, PA, Sofia, MJ, Du, J, Bao, H, Murakami, E, Mosley, RT

J Med Chem 2011
Participants
Participates
Catalyst Activity

N6-mAMP deaminase activity of ADAL:Zn [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!