N6-methyl-AMP + H2O => IMP + methylamine

Stable Identifier
R-HSA-2161187
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Deamination of N6-methyl-AMP to form IMP
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N6-methyl-AMP + H2O => IMP + methylamine
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Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of N6-methyl-AMP and water to form IMP and methylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
adenosine deaminase activity of ADAL:Zn [cytosol]
Physical Entity
ADAL:Zn [cytosol]
Activity
adenosine deaminase activity (0004000)
Orthologous Events
N6-methyl-AMP + H2O => IMP + methylamine (Caenorhabditis elegans)
N6-methyl-AMP + H2O => IMP + methylamine (Canis familiaris)
N6-methyl-AMP + H2O => IMP + methylamine (Danio rerio)
N6-methyl-AMP + H2O => IMP + methylamine (Drosophila melanogaster)
N6-methyl-AMP + H2O => IMP + methylamine (Gallus gallus)
N6-methyl-AMP + H2O => IMP + methylamine (Mus musculus)
N6-methyl-AMP + H2O => IMP + methylamine (Sus scrofa)
N6-methyl-AMP + H2O => IMP + methylamine (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2012-03-14)
Reviewed
Jassal, B  (2012-03-16)
Created
D'Eustachio, P  (2012-03-09)
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