Reactome | ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine

ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine

Stable Identifier

R-HSA-2161187

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Synonyms

N6-methyl-AMP(2-) + H2O + H+ => IMP(2-) + methylamine, Deamination of N6-methyl-AMP to form IMP

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ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine

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Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of N6-methyl-AMP and water to form IMP and methylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011). Scaletti et al. (2021) suggest that under physiological conditions this reaction could enable the detoxification and salvage of methylated adenosine nucleotides.

Literature References

PubMed ID	Title	Journal	Year
32144205	MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool Vallin, KS, Jemth, AS, Scaletti, ER, Stenmark, P, Helleday, T, Sarno, A, Warpman Berglund, U, Bräutigam, L	J Biol Chem	2020
21755941	Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates Furman, PA, Sofia, MJ, Du, J, Bao, H, Murakami, E, Mosley, RT	J Med Chem	2011