N6-methyl-AMP + H2O => IMP + methylamine

Stable Identifier
R-HSA-2161187
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Deamination of N6-methyl-AMP to form IMP
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
N6-methyl-AMP + H2O => IMP + methylamine
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of N6-methyl-AMP and water to form IMP and methylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
adenosine deaminase activity of ADAL:Zn [cytosol]
Physical Entity
ADAL:Zn [cytosol]
Activity
adenosine deaminase activity (0004000)
Orthologous Events
N6-methyl-AMP + H2O => IMP + methylamine (Caenorhabditis elegans)
N6-methyl-AMP + H2O => IMP + methylamine (Canis familiaris)
N6-methyl-AMP + H2O => IMP + methylamine (Danio rerio)
N6-methyl-AMP + H2O => IMP + methylamine (Drosophila melanogaster)
N6-methyl-AMP + H2O => IMP + methylamine (Gallus gallus)
N6-methyl-AMP + H2O => IMP + methylamine (Mus musculus)
N6-methyl-AMP + H2O => IMP + methylamine (Rattus norvegicus)
N6-methyl-AMP + H2O => IMP + methylamine (Sus scrofa)
N6-methyl-AMP + H2O => IMP + methylamine (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2012-03-14)
Reviewed
Jassal, B  (2012-03-16)
Created
D'Eustachio, P  (2012-03-09)