Reactome | TGFBR1 is recruited to tight junctions by PARD6A

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TGFBR1 is recruited to tight junctions by PARD6A Show undefined attributes

authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
category	binding
compartment	[Compartment:204883] cell junction [Compartment:876] plasma membrane
created	[InstanceEdit:2134512] Orlic-Milacic, M, 2012-02-23
dbId	2134506
displayName	TGFBR1 is recruited to tight junctions by PARD6A
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10
eventOf	[Pathway:R-HSA-2173791] TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) - Homo sapiens
followingEvent	[Reaction:R-HSA-2134519] TGFBR2 is recruited to tight junctions after TGF-beta stimulation - Homo sapiens
inferredFrom	[Reaction:R-NUL-2161147] TGFBR1 is recruited to tight junction by binding Pard6a - Homo sapiens
input	2 × [Complex:R-HSA-2187279] TGFBR1:FKBP1A [plasma membrane] [Complex:R-HSA-2134514] Tight Junction Complex:PARD6A:RHOA [cell junction]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2134511] Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity [LiteratureReference:2134508] Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis [LiteratureReference:2134494] Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin [LiteratureReference:419972] The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM) [LiteratureReference:419982] The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TGFBR1 is recruited to tight junctions by PARD6A
output	[Complex:R-HSA-2134509] Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14
revised	[InstanceEdit:3009235] Orlic-Milacic, M, 2013-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2134506
summation	[Summation:2134517] TGFBR1 binds to PARD6A, a component of tight junctions, and ...

Referrals

(hasEvent)	[Pathway:R-HSA-2173791] TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
(precedingEvent)	[Reaction:R-HSA-2134519] TGFBR2 is recruited to tight junctions after TGF-beta stimulation
(inferredTo)	[Reaction:R-NUL-2161147] TGFBR1 is recruited to tight junction by binding Pard6a