Reactome | Internalization of MHC II:Ii clathrin coated vesicle

Schema > BlackBoxEvent > Entries

Internalization of MHC II:Ii clathrin coated vesicle Show undefined attributes

authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
catalystActivity	[CatalystActivity:445092] GTPase activity of Dynamin-1/2/3 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:24339] clathrin-coated endocytic vesicle membrane
created	[InstanceEdit:2130630] Garapati, P V, 2012-02-21
dbId	2130725
displayName	Internalization of MHC II:Ii clathrin coated vesicle
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
eventOf	[Pathway:R-HSA-2132295] MHC class II antigen presentation - Homo sapiens
followingEvent	[Reaction:R-HSA-2130486] Uncoating of clathrin-coated vesicles and fusion with endosomes - Homo sapiens
input	[Complex:R-HSA-2130309] Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-HSA-177495] SH3GL2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2130543] AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class II to endosomes [LiteratureReference:2130499] Decreased endosomal delivery of major histocompatibility complex class II-invariant chain complexes in dynamin-deficient cells [LiteratureReference:2130726] Direct transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimera [LiteratureReference:2130606] Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Internalization of MHC II:Ii clathrin coated vesicle
orthologousEvent	[BlackBoxEvent:R-GGA-2130725] Internalization of MHC II:Ii clathrin coated vesicle - Gallus gallus [BlackBoxEvent:R-SSC-2130725] Internalization of MHC II:Ii clathrin coated vesicle - Sus scrofa [BlackBoxEvent:R-BTA-2130725] Internalization of MHC II:Ii clathrin coated vesicle - Bos taurus [BlackBoxEvent:R-CFA-2130725] Internalization of MHC II:Ii clathrin coated vesicle - Canis familiaris [BlackBoxEvent:R-RNO-2130725] Internalization of MHC II:Ii clathrin coated vesicle - Rattus norvegicus [BlackBoxEvent:R-MMU-2130725] Internalization of MHC II:Ii clathrin coated vesicle - Mus musculus
output	[Complex:R-HSA-2130331] Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-2130640] Recruitment of clathrin coated vesicle by Ii - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2130725
summation	[Summation:2130657] MHC II:Ii complexes are internalized in to the endocytic cla...

Referrals

(hasEvent)	[Pathway:R-HSA-2132295] MHC class II antigen presentation
(precedingEvent)	[Reaction:R-HSA-2130486] Uncoating of clathrin-coated vesicles and fusion with endosomes