Reactome | Internalization of MHC II:Ii clathrin coated vesicle

Schema > BlackBoxEvent > Entries

Internalization of MHC II:Ii clathrin coated vesicle Show undefined attributes

catalystActivity	[CatalystActivity:10368131] GTPase activity of Dynamin-1/2/3 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:24339] clathrin-coated endocytic vesicle membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10386654
displayName	Internalization of MHC II:Ii clathrin coated vesicle
eventOf	[Pathway:R-BTA-2132295] MHC class II antigen presentation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-2130486] Uncoating of clathrin-coated vesicles and fusion with endosomes - Bos taurus
inferredFrom	[BlackBoxEvent:R-HSA-2130725] Internalization of MHC II:Ii clathrin coated vesicle - Homo sapiens
input	[Complex:R-BTA-2130309] Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-BTA-177495] SH3GL2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Internalization of MHC II:Ii clathrin coated vesicle
output	[Complex:R-BTA-2130331] Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-BTA-2130640] Recruitment of clathrin coated vesicle by Ii - Bos taurus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-2130725
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2132295] MHC class II antigen presentation
(precedingEvent)	[Reaction:R-BTA-2130486] Uncoating of clathrin-coated vesicles and fusion with endosomes
(inferredTo)	[BlackBoxEvent:R-HSA-2130725] Internalization of MHC II:Ii clathrin coated vesicle