Reactome | Translocation of TGN-lysosome vesicle to lysosome

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Translocation of TGN-lysosome vesicle to lysosome Show undefined attributes

authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
catalystActivity	[CatalystActivity:2213237] GTPase activity of Dynamin [cytosol]
category	transition
compartment	[Compartment:263163] trans-Golgi network membrane [Compartment:70101] cytosol
created	[InstanceEdit:2130630] Garapati, P V, 2012-02-21
dbId	2130641
displayName	Translocation of TGN-lysosome vesicle to lysosome
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
eventOf	[Pathway:R-HSA-2132295] MHC class II antigen presentation - Homo sapiens
followingEvent	[Reaction:R-HSA-2213236] TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome - Homo sapiens
input	[Complex:R-HSA-2130552] AP-1 Clathrin coated nonameric complex [trans-Golgi network membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2130462] A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway [LiteratureReference:2130464] MHC class II-associated invariant chain contains a sorting signal for endosomal compartments [LiteratureReference:2130454] Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain [LiteratureReference:2130374] Expression of major histocompatibility complex class II molecules in HeLa cells promotes the recruitment of AP-1 Golgi-specific assembly proteins on Golgi membranes [LiteratureReference:2130726] Direct transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimera [LiteratureReference:2130580] Medium chains of adaptor complexes AP-1 and AP-2 recognize leucine-based sorting signals from the invariant chain [LiteratureReference:2130498] The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Translocation of TGN-lysosome vesicle to lysosome
orthologousEvent	[Reaction:R-XTR-2130641] Translocation of TGN-lysosome vesicle to lysosome - Xenopus tropicalis [Reaction:R-DRE-2130641] Translocation of TGN-lysosome vesicle to lysosome - Danio rerio [Reaction:R-SSC-2130641] Translocation of TGN-lysosome vesicle to lysosome - Sus scrofa [Reaction:R-BTA-2130641] Translocation of TGN-lysosome vesicle to lysosome - Bos taurus [Reaction:R-CFA-2130641] Translocation of TGN-lysosome vesicle to lysosome - Canis familiaris [Reaction:R-RNO-2130641] Translocation of TGN-lysosome vesicle to lysosome - Rattus norvegicus [Reaction:R-MMU-2130641] Translocation of TGN-lysosome vesicle to lysosome - Mus musculus
output	[CandidateSet:R-HSA-2213185] Dynamin [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-HSA-2213234] TGN-lysosome vesicle with nonameric complex [trans-Golgi network membrane]
precedingEvent	[BlackBoxEvent:R-HSA-2130619] TGN-lysosomal vesicle coat assembly - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2130641
summation	[Summation:2213089] Budding vesicles loaded with the nonameric complex bud off f...

Referrals

(hasEvent)	[Pathway:R-HSA-2132295] MHC class II antigen presentation
(precedingEvent)	[Reaction:R-HSA-2213236] TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome

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