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Schema
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Entries
Translocation of TGN-lysosome vesicle to lysosome
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authored
[InstanceEdit:2132294] Garapati, P V, 2012-02-21
catalystActivity
[CatalystActivity:2213237] GTPase activity of Dynamin [cytosol]
category
transition
compartment
[Compartment:263163] trans-Golgi network membrane
[Compartment:70101] cytosol
created
[InstanceEdit:2130630] Garapati, P V, 2012-02-21
dbId
2130641
displayName
Translocation of TGN-lysosome vesicle to lysosome
edited
[InstanceEdit:2132294] Garapati, P V, 2012-02-21
eventOf
[Pathway:R-HSA-2132295] MHC class II antigen presentation - Homo sapiens
followingEvent
[Reaction:R-HSA-2213236] TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome - Homo sapiens
input
[Complex:R-HSA-2130552] AP-1 Clathrin coated nonameric complex [trans-Golgi network membrane]
[SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2130462] A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway
[LiteratureReference:2130464] MHC class II-associated invariant chain contains a sorting signal for endosomal compartments
[LiteratureReference:2130454] Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain
[LiteratureReference:2130374] Expression of major histocompatibility complex class II molecules in HeLa cells promotes the recruitment of AP-1 Golgi-specific assembly proteins on Golgi membranes
[LiteratureReference:2130726] Direct transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimera
[LiteratureReference:2130580] Medium chains of adaptor complexes AP-1 and AP-2 recognize leucine-based sorting signals from the invariant chain
[LiteratureReference:2130498] The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains
modified
[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name
Translocation of TGN-lysosome vesicle to lysosome
orthologousEvent
[Reaction:R-GGA-2130641] Translocation of TGN-lysosome vesicle to lysosome - Gallus gallus
[Reaction:R-XTR-2130641] Translocation of TGN-lysosome vesicle to lysosome - Xenopus tropicalis
[Reaction:R-DRE-2130641] Translocation of TGN-lysosome vesicle to lysosome - Danio rerio
[Reaction:R-SSC-2130641] Translocation of TGN-lysosome vesicle to lysosome - Sus scrofa
[Reaction:R-BTA-2130641] Translocation of TGN-lysosome vesicle to lysosome - Bos taurus
[Reaction:R-CFA-2130641] Translocation of TGN-lysosome vesicle to lysosome - Canis familiaris
[Reaction:R-RNO-2130641] Translocation of TGN-lysosome vesicle to lysosome - Rattus norvegicus
[Reaction:R-MMU-2130641] Translocation of TGN-lysosome vesicle to lysosome - Mus musculus
output
[CandidateSet:R-HSA-2213185] Dynamin [cytosol]
[SimpleEntity:R-ALL-29420] GDP [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
[Complex:R-HSA-2213234] TGN-lysosome vesicle with nonameric complex [trans-Golgi network membrane]
precedingEvent
[BlackBoxEvent:R-HSA-2130619] TGN-lysosomal vesicle coat assembly - Homo sapiens
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2130641
summation
[Summation:2213089] Budding vesicles loaded with the nonameric complex bud off f...
Referrals
(hasEvent)
[Pathway:R-HSA-2132295] MHC class II antigen presentation
(precedingEvent)
[Reaction:R-HSA-2213236] TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome
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