Reactome | Cleavage of lip22 to lip10

Schema > Reaction > Entries

Cleavage of lip22 to lip10 Show undefined attributes

authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
catalystActivity	[CatalystActivity:2130341] cysteine-type endopeptidase activity of Cathepsin [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:2130630] Garapati, P V, 2012-02-21
dbId	2130504
displayName	Cleavage of lip22 to lip10
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
eventOf	[Pathway:R-HSA-2132295] MHC class II antigen presentation - Homo sapiens
followingEvent	[Reaction:R-HSA-2130349] Generation of CLIP from lip10 - Homo sapiens
input	[Complex:R-HSA-2130680] MHC II:lip22 nonamer [lysosomal membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2130403] Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs [LiteratureReference:2130364] Potential sites for processing of the human invariant chain by cathepsins D and E [LiteratureReference:2130408] Presentation of antigens by MHC class II molecules: getting the most out of them [LiteratureReference:2130590] Proteolysis and antigen presentation by MHC class II molecules
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	Cleavage of lip22 to lip10
orthologousEvent	[Reaction:R-DRE-2130504] Cleavage of lip22 to lip10 - Danio rerio [Reaction:R-SSC-2130504] Cleavage of lip22 to lip10 - Sus scrofa [Reaction:R-BTA-2130504] Cleavage of lip22 to lip10 - Bos taurus [Reaction:R-CFA-2130504] Cleavage of lip22 to lip10 - Canis familiaris [Reaction:R-RNO-2130504] Cleavage of lip22 to lip10 - Rattus norvegicus [Reaction:R-MMU-2130504] Cleavage of lip22 to lip10 - Mus musculus
output	[Complex:R-HSA-2130723] MHC II:lip10 nonamer [lysosomal membrane]
precedingEvent	[Reaction:R-HSA-2130336] Initial proteolyis of Ii by aspartic proteases to lip22 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2130504
summation	[Summation:2130453] The cleavage of lip22 occurs in residues 115-125, closer to ...

Referrals

(hasEvent)	[Pathway:R-HSA-2132295] MHC class II antigen presentation
(precedingEvent)	[Reaction:R-HSA-2130349] Generation of CLIP from lip10