Reactome | Initial proteolyis of Ii by aspartic proteases to lip22

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Initial proteolyis of Ii by aspartic proteases to lip22 Show undefined attributes

authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
catalystActivity	[CatalystActivity:350178] cysteine-type endopeptidase activity of LGMN [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:2130630] Garapati, P V, 2012-02-21
dbId	2130336
displayName	Initial proteolyis of Ii by aspartic proteases to lip22
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
eventOf	[Pathway:R-HSA-2132295] MHC class II antigen presentation - Homo sapiens
followingEvent	[Reaction:R-HSA-2130504] Cleavage of lip22 to lip10 - Homo sapiens
input	[Complex:R-HSA-2130532] Nonameric complex [lysosomal membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2130473] Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation [LiteratureReference:2130567] Endosomal aspartic proteinases are required for invariant-chain processing
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	Initial proteolyis of Ii by aspartic proteases to lip22
orthologousEvent	[Reaction:R-DRE-2130336] Initial proteolyis of Ii by aspartic proteases to lip22 - Danio rerio [Reaction:R-SSC-2130336] Initial proteolyis of Ii by aspartic proteases to lip22 - Sus scrofa [Reaction:R-BTA-2130336] Initial proteolyis of Ii by aspartic proteases to lip22 - Bos taurus [Reaction:R-CFA-2130336] Initial proteolyis of Ii by aspartic proteases to lip22 - Canis familiaris [Reaction:R-RNO-2130336] Initial proteolyis of Ii by aspartic proteases to lip22 - Rattus norvegicus [Reaction:R-MMU-2130336] Initial proteolyis of Ii by aspartic proteases to lip22 - Mus musculus
output	[Complex:R-HSA-2130680] MHC II:lip22 nonamer [lysosomal membrane]
precedingEvent	[BlackBoxEvent:R-HSA-2213235] Trafficking of nonameric complex in the endocytic pathway - Homo sapiens [Reaction:R-HSA-2213236] TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2130336
summation	[Summation:2130322] Within acidic endocytic compartments Ii is proteolytically c...

Referrals

(precedingEvent)	[Reaction:R-HSA-2130504] Cleavage of lip22 to lip10
(hasEvent)	[Pathway:R-HSA-2132295] MHC class II antigen presentation

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