Reactome | Cleavage of lip22 to lip10

Schema > Reaction > Entries

Cleavage of lip22 to lip10 Show undefined attributes

catalystActivity	[CatalystActivity:10386601] cysteine-type endopeptidase activity of Cathepsin [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10386603
displayName	Cleavage of lip22 to lip10
eventOf	[Pathway:R-BTA-2132295] MHC class II antigen presentation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-2130349] Generation of CLIP from lip10 - Bos taurus
inferredFrom	[Reaction:R-HSA-2130504] Cleavage of lip22 to lip10 - Homo sapiens
input	[Complex:R-BTA-2130680] MHC II:lip22 nonamer [lysosomal membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Cleavage of lip22 to lip10
output	[Complex:R-BTA-2130723] MHC II:lip10 nonamer [lysosomal membrane]
precedingEvent	[Reaction:R-BTA-2130336] Initial proteolyis of Ii by aspartic proteases to lip22 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2130504
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2132295] MHC class II antigen presentation
(precedingEvent)	[Reaction:R-BTA-2130349] Generation of CLIP from lip10
(inferredTo)	[Reaction:R-HSA-2130504] Cleavage of lip22 to lip10

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