Reactome | Initial proteolyis of Ii by aspartic proteases to lip22

Schema > Reaction > Entries

Initial proteolyis of Ii by aspartic proteases to lip22 Show undefined attributes

catalystActivity	[CatalystActivity:10601350] cysteine-type endopeptidase activity of LGMN [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10601352
displayName	Initial proteolyis of Ii by aspartic proteases to lip22
eventOf	[Pathway:R-DRE-2132295] MHC class II antigen presentation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-2130504] Cleavage of lip22 to lip10 - Danio rerio
inferredFrom	[Reaction:R-HSA-2130336] Initial proteolyis of Ii by aspartic proteases to lip22 - Homo sapiens
input	[Complex:R-DRE-2130532] Nonameric complex [lysosomal membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Initial proteolyis of Ii by aspartic proteases to lip22
output	[Complex:R-DRE-2130680] MHC II:lip22 nonamer [lysosomal membrane]
precedingEvent	[BlackBoxEvent:R-DRE-2213235] Trafficking of nonameric complex in the endocytic pathway - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-2130336
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2132295] MHC class II antigen presentation
(precedingEvent)	[Reaction:R-DRE-2130504] Cleavage of lip22 to lip10
(inferredTo)	[Reaction:R-HSA-2130336] Initial proteolyis of Ii by aspartic proteases to lip22

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