Caspase 3-mediated cleavage of DFF45 (117)

Stable Identifier
R-HSA-211190
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Caspase-3 cleaves the DFF45 subunit of the DFF45:DFF40 complex at two sites to generate an active DNA fragmentation factor. One site of cleavage is between residues 117,118 (Liu et al., 1997).

Literature References
PubMed ID Title Journal Year
9108473 DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

Liu, X, Zou, H, Slaughter, C, Wang, X

Cell 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of active caspase-3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created