Caspase 3-mediated cleavage of DFF45 (117)

Stable Identifier
R-HSA-211190
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Caspase 3-mediated cleavage of DFF45 (117)
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Caspase-3 cleaves the DFF45 subunit of the DFF45:DFF40 complex at two sites to generate an active DNA fragmentation factor. One site of cleavage is between residues 117,118 (Liu et al., 1997).
Literature References
PubMed ID Title Journal Year
9108473 DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

Liu, X, Zou, H, Slaughter, C, Wang, X

Cell 1997
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Input
Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of active caspase-3 [nucleoplasm]

Physical Entity
active caspase-3 [nucleoplasm] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase 3-mediated cleavage of DFF45 (117) (Bos taurus)
Caspase 3-mediated cleavage of DFF45 (117) (Canis familiaris)
Caspase 3-mediated cleavage of DFF45 (117) (Danio rerio)
Caspase 3-mediated cleavage of DFF45 (117) (Drosophila melanogaster)
Caspase 3-mediated cleavage of DFF45 (117) (Gallus gallus)
Caspase 3-mediated cleavage of DFF45 (117) (Mus musculus)
Caspase 3-mediated cleavage of DFF45 (117) (Rattus norvegicus)
Caspase 3-mediated cleavage of DFF45 (117) (Sus scrofa)
Caspase 3-mediated cleavage of DFF45 (117) (Xenopus tropicalis)
Authored
Matthews, L  (2008-01-29)
Reviewed
Widlak, P  (2008-05-08)
Created
Matthews, L  (2008-01-29)
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