Reactome | AKT phosphorylates FOXO1A

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AKT phosphorylates FOXO1A Show undefined attributes

authored	[InstanceEdit:351500] Ferrer, J, Tello-Ruiz, MK, 2008-05-23
catalystActivity	[CatalystActivity:199274] protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:211152] D'Eustachio, P, 2008-01-28 22:58:31
dbId	211164
displayName	AKT phosphorylates FOXO1A
edited	[InstanceEdit:349681] D'Eustachio, P, 2008-05-12 21:43:33
eventOf	[Pathway:R-HSA-211163] AKT-mediated inactivation of FOXO1A - Homo sapiens
followingEvent	[Reaction:R-HSA-211178] Phosphorylated FOXO1A is excluded from the nucleus - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-199300] FOXO1 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:211151] Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding [LiteratureReference:211262] Kinetic mechanism of AKT/PKB enzyme family [LiteratureReference:166891] Cell cycle and death control: long live Forkheads
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	AKT phosphorylates FOXO1A
orthologousEvent	[Reaction:R-CEL-211164] AKT phosphorylates FOXO1A - Caenorhabditis elegans [Reaction:R-DME-211164] AKT phosphorylates FOXO1A - Drosophila melanogaster [Reaction:R-GGA-211164] AKT phosphorylates FOXO1A - Gallus gallus [Reaction:R-DRE-211164] AKT phosphorylates FOXO1A - Danio rerio [Reaction:R-RNO-211164] AKT phosphorylates FOXO1A - Rattus norvegicus [Reaction:R-MMU-211164] AKT phosphorylates FOXO1A - Mus musculus
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-199306] p-T24,S256,S319-FOXO1 [nucleoplasm]
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:349683] Jensen, J, 2008-05-12 21:46:53
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-211164
summation	[Summation:211171] One or more of the isoforms of AKT catalyzes the phosphoryla...

Referrals

(hasEvent)	[Pathway:R-HSA-211163] AKT-mediated inactivation of FOXO1A
(precedingEvent)	[Reaction:R-HSA-211178] Phosphorylated FOXO1A is excluded from the nucleus