Reactome | SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex

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SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19
dbId	209125
displayName	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex
edited	[InstanceEdit:744685] Jupe, S, 2010-05-17
eventOf	[Pathway:R-HSA-9020702] Interleukin-1 signaling - Homo sapiens
figure	[Figure:208712] /figures/DrosTollImdA18.jpg
input	[Complex:R-HSA-206748] BTRC:CUL1:RBX1:SKP1 [cytosol] [Complex:R-HSA-206842] NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208148] Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha [LiteratureReference:208176] Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP [LiteratureReference:196245] The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro [LiteratureReference:208375] Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP [LiteratureReference:208290] Identification of the receptor component of the IkappaBalpha-ubiquitin ligase [LiteratureReference:208326] Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex
orthologousEvent	[Reaction:R-BTA-209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex - Bos taurus [Reaction:R-DME-209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex - Drosophila melanogaster [Reaction:R-GGA-209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex - Gallus gallus [Reaction:R-RNO-209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex - Rattus norvegicus [Reaction:R-MMU-209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex - Mus musculus
output	[Complex:R-HSA-206891] NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol]
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:744680] Pinteaux, E, 2010-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-209125
summation	[Summation:206484] Human beta-TrCP forms part of the SCF E3 ubiquitin ligase co...

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(hasEvent)

[Pathway:R-HSA-9020702] Interleukin-1 signaling