Reactome | SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex

SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex

Stable Identifier

R-HSA-209125

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex

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Human beta-TrCP forms part of the SCF E3 ubiquitin ligase complex which binds to phosphorylated residues Ser32 and Ser 36 at the IKK target motif in IKBA complex with P65:P50 heterodimer.

Literature References

PubMed ID	Title	Journal	Year
9990852	The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro Strack, P, Elledge, SJ, Beer-Romero, P, Chu, CY, Winston, JT, Harper, JW	Genes Dev	1999
10514433	Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha Matsumoto, M, Hatakeyama, S, Shirane, M, Hattori, K, Nakayama, K	J Biol Chem	1999
7628694	Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway Scherer, D, Chen, Z, Hagler, J, Palombella, VJ, Ballard, D, Maniatis, T, Melandri, F	Genes Dev	1995
9990853	Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP Jiang, J, Spencer, E, Chen, ZJ	Genes Dev	1999
10075690	Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP Margottin, F, Bachelerie, F, Kohl, A, Benarous, R, Concordet, JP, Durand, H, Arenzana-Seisdedos, F, Renard, P, Kroll, M	J Biol Chem	1999
9859996	Identification of the receptor component of the IkappaBalpha-ubiquitin ligase Andersen, JS, Mann, M, Lavon, I, Manning, AM, Hatzubai, A, Amit, S, Mercurio, F, Yaron, A, Davis, M, Ben-Neriah, Y	Nature	1998