Human beta-TrCP forms part of the SCF E3 ubiquitin ligase complex which binds to phosphorylated residues Ser32 and Ser 36 at the IKK target motif in IKBA complex with P65:P50 heterodimer.
Hattori, K, Hatakeyama, S, Shirane, M, Matsumoto, M, Nakayama, K
Winston, JT, Strack, P, Beer-Romero, P, Chu, CY, Elledge, SJ, Harper, JW
Chen, Z, Hagler, J, Palombella, VJ, Melandri, F, Scherer, D, Ballard, D, Maniatis, T
Spencer, E, Jiang, J, Chen, ZJ
Kroll, M, Margottin, F, Kohl, A, Renard, P, Durand, H, Concordet, JP, Bachelerie, F, Arenzana-Seisdedos, F, Benarous, R
Yaron, A, Hatzubai, A, Davis, M, Lavon, I, Amit, S, Manning, AM, Andersen, JS, Mann, M, Mercurio, F, Ben-Neriah, Y
© 2021 Reactome