Reactome | SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex

SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex

Stable Identifier

R-HSA-209125

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Human beta-TrCP forms part of the SCF E3 ubiquitin ligase complex which binds to phosphorylated residues Ser32 and Ser 36 at the IKK target motif in IKBA complex with P65:P50 heterodimer.

Literature References

PubMed ID	Title	Journal	Year
9990852	The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro Strack, P, Elledge, SJ, Beer-Romero, P, Chu, CY, Winston, JT, Harper, JW	Genes Dev	1999
10514433	Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha Matsumoto, M, Hatakeyama, S, Shirane, M, Hattori, K, Nakayama, K	J Biol Chem	1999
7628694	Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway Scherer, D, Chen, Z, Hagler, J, Palombella, VJ, Ballard, D, Maniatis, T, Melandri, F	Genes Dev	1995
9990853	Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP Jiang, J, Spencer, E, Chen, ZJ	Genes Dev	1999
10075690	Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP Margottin, F, Bachelerie, F, Kohl, A, Benarous, R, Concordet, JP, Durand, H, Arenzana-Seisdedos, F, Renard, P, Kroll, M	J Biol Chem	1999
9859996	Identification of the receptor component of the IkappaBalpha-ubiquitin ligase Andersen, JS, Mann, M, Lavon, I, Manning, AM, Hatzubai, A, Amit, S, Mercurio, F, Yaron, A, Davis, M, Ben-Neriah, Y	Nature	1998