Reactome | IDUA hydrolyses Heparan sulfate chain(6)

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IDUA hydrolyses Heparan sulfate chain(6) Show undefined attributes

authored	[InstanceEdit:2090024] Jassal, B, 2012-02-06
catalystActivity	[CatalystActivity:1678683] L-iduronidase activity of IDUA [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:2090024] Jassal, B, 2012-02-06
dbId	2090037
diseaseReaction	[FailedReaction:R-HSA-2206299] Defective IDUA does not hydrolyse Heparan sulfate chain(6) - Homo sapiens
displayName	IDUA hydrolyses Heparan sulfate chain(6)
edited	[InstanceEdit:2090024] Jassal, B, 2012-02-06
eventOf	[Pathway:R-HSA-2024096] HS-GAG degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-2090043] SGSH hydrolyses Heparan sulfate chain(7) - Homo sapiens
input	[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [SimpleEntity:R-ALL-2090055] IdoA-GlcNS3S- group [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1678628] Human alpha-L-iduronidase: cDNA isolation and expression [LiteratureReference:1678646] Mucopolysaccharidosis type I: characterization of novel mutations affecting alpha-L-iduronidase activity
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	IDUA hydrolyses Heparan sulfate chain(6) Alpha-L-iduronidase (IDUA) hydrolyses another unsulfated alpha-L-iduronosidic linkage in heparan sulfate
orthologousEvent	[Reaction:R-BTA-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Bos taurus [Reaction:R-DDI-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Dictyostelium discoideum [Reaction:R-DME-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Drosophila melanogaster [Reaction:R-GGA-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Gallus gallus [Reaction:R-XTR-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Xenopus tropicalis [Reaction:R-DRE-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Danio rerio [Reaction:R-SSC-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Sus scrofa [Reaction:R-CFA-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Canis familiaris [Reaction:R-RNO-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Rattus norvegicus [Reaction:R-MMU-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Mus musculus
output	[SimpleEntity:R-ALL-1678617] aldehydo-L-iduronic acid [lysosomal lumen] [SimpleEntity:R-ALL-2090070] GlcNS3S- group [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1678650] IDS hydrolyses Heparan sulfate chain(5) - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2090037
summation	[Summation:1678630] The lysosomal enzyme alpha-L-iduronidase (IDUA) cleaves the ...
updateTrackers	[UpdateTracker:9953735] Update Tracker - [Reaction:2090037] IDUA hydrolyses Heparan sulfate chain(6) - v93:[modifyText] [UpdateTracker:9788383] Update Tracker - [Reaction:2090037] IDUA hydrolyses Heparan sulfate chain(6) - v42:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9953735] Update Tracker - [Reaction:2090037] IDUA hydrolyses Heparan sulfate chain(6) - v93:[modifyText] [UpdateTracker:9788383] Update Tracker - [Reaction:2090037] IDUA hydrolyses Heparan sulfate chain(6) - v42:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-2206299] Defective IDUA does not hydrolyse Heparan sulfate chain(6)
(hasEvent)	[Pathway:R-HSA-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-HSA-2090043] SGSH hydrolyses Heparan sulfate chain(7)