Reactome | IDS hydrolyses Heparan sulfate chain(5)

Schema > Reaction > Entries

IDS hydrolyses Heparan sulfate chain(5) Show undefined attributes

authored	[InstanceEdit:1678699] Jassal, B, 2011-10-19
catalystActivity	[CatalystActivity:1678645] iduronate-2-sulfatase activity of IDS dimer [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:1678699] Jassal, B, 2011-10-19
dbId	1678650
displayName	IDS hydrolyses Heparan sulfate chain(5)
edited	[InstanceEdit:1678699] Jassal, B, 2011-10-19
eventOf	[Pathway:R-HSA-2024096] HS-GAG degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Homo sapiens
input	[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [SimpleEntity:R-ALL-2090080] Heparan sulfate chain(5) [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1678613] Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	IDS hydrolyses Heparan sulfate chain(5)
orthologousEvent	[Reaction:R-DME-1678650] IDS hydrolyses Heparan sulfate chain(5) - Drosophila melanogaster [Reaction:R-GGA-1678650] IDS hydrolyses Heparan sulfate chain(5) - Gallus gallus [Reaction:R-XTR-1678650] IDS hydrolyses Heparan sulfate chain(5) - Xenopus tropicalis [Reaction:R-DRE-1678650] IDS hydrolyses Heparan sulfate chain(5) - Danio rerio [Reaction:R-SSC-1678650] IDS hydrolyses Heparan sulfate chain(5) - Sus scrofa [Reaction:R-BTA-1678650] IDS hydrolyses Heparan sulfate chain(5) - Bos taurus [Reaction:R-CFA-1678650] IDS hydrolyses Heparan sulfate chain(5) - Canis familiaris [Reaction:R-RNO-1678650] IDS hydrolyses Heparan sulfate chain(5) - Rattus norvegicus [Reaction:R-MMU-1678650] IDS hydrolyses Heparan sulfate chain(5) - Mus musculus
output	[SimpleEntity:R-ALL-2090055] Heparan sulfate chain(6) [lysosomal lumen] [SimpleEntity:R-ALL-1606845] SO4(2-) [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1678742] NAGLU hydrolyses Heparan sulfate chain(4) - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1678650
summation	[Summation:1678649] Iduronate 2sulfatase (IDS) hydrolyses 2-sulfate groups from ...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9036046] Defective IDS does not hydrolyse Heparan sulfate chain(5)
(hasEvent)	[Pathway:R-HSA-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-HSA-2090037] IDUA hydrolyses Heparan sulfate chain(6)