Reactome | IDUA hydrolyses Heparan sulfate chain(6)

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IDUA hydrolyses Heparan sulfate chain(6) Show undefined attributes

catalystActivity	[CatalystActivity:10271143] L-iduronidase activity of IDUA [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10276446
displayName	IDUA hydrolyses Heparan sulfate chain(6)
eventOf	[Pathway:R-CFA-2024096] HS-GAG degradation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-2090043] SGSH hydrolyses Heparan sulfate chain(7) - Canis familiaris
inferredFrom	[Reaction:R-HSA-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Homo sapiens
input	[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [SimpleEntity:R-ALL-2090055] IdoA-GlcNS3S- group [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	IDUA hydrolyses Heparan sulfate chain(6) Alpha-L-iduronidase (IDUA) hydrolyses another unsulfated alpha-L-iduronosidic linkage in heparan sulfate
output	[SimpleEntity:R-ALL-1678617] aldehydo-L-iduronic acid [lysosomal lumen] [SimpleEntity:R-ALL-2090070] GlcNS3S- group [lysosomal lumen]
precedingEvent	[Reaction:R-CFA-1678650] IDS hydrolyses Heparan sulfate chain(5) - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2090037
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-CFA-2090043] SGSH hydrolyses Heparan sulfate chain(7)
(inferredTo)	[Reaction:R-HSA-2090037] IDUA hydrolyses Heparan sulfate chain(6)

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