Reactome | FGFR3 (4;14) translocation mutants [plasma membrane]

Schema > CandidateSet > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2038386] Dimerization of FGFR3 t(4;14) translocation mutants - Homo sapiens [Reaction:R-HSA-2038386] Dimerization of FGFR3 t(4;14) translocation mutants - Homo sapiens
created	[InstanceEdit:2038373] Rothfels, K, 2012-01-09
crossReference	[DatabaseIdentifier:12020798] Mondo:0009693
dbId	2038374
disease	[Disease:1500689] cancer [Disease:1614388] multiple myeloma
displayName	FGFR3 (4;14) translocation mutants [plasma membrane]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-2038357] FGFR3 [plasma membrane] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-1614419] FGFR3 R248C [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1614424] FGFR3 Y373C [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1614398] FGFR3 G380R [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2018740] FGFR3 G382D [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1614400] FGFR3 K650E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1614387] FGFR3 805fs*141 [plasma membrane] - Homo sapiens
inDisease	true
maxDepth	2
name	FGFR3 (4;14) translocation mutants
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2038374

(input)	[Reaction:R-HSA-2038386] Dimerization of FGFR3 t(4;14) translocation mutants
(diseaseEntity)	[EntityFunctionalStatus:5654493] gain_of_function of FGFR3 (4;14) translocation mutants [plasma membrane]