Reactome | FGFR3 805fs*141 [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2038350] FGFR3 795fs*139STOP mutant dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:1614389] Rothfels, K, 2011-09-28
dbId	1614387
disease	[Disease:1614388] multiple myeloma [Disease:1625209] thanatophoric dysplasia [Disease:2032940] bone development disease [Disease:1500689] cancer
displayName	FGFR3 805fs*141 [plasma membrane]
endCoordinate	806
hasModifiedResidue	[FragmentReplacedModification:9767528] Replacement of residues 806 to 806 by TRATGPQQCEGSLAAHPAAGAQPLPGMRLSADGETATQSFGLCVCVCVCVCVCTSACACVRAHLASRCRGTLGVPAAVQRSPDWCCSTEGPLGWGDPVQNVSGPTRWDPRGAGSWARHGSGLCLCTTGHHRVGLGPSHTQS
inDisease	true
literatureReference	[LiteratureReference:1637849] Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma [LiteratureReference:2038356] Stop codon FGFR3 mutations in thanatophoric dwarfism type 1
memberOf	[CandidateSet:R-HSA-2038374] FGFR3 (4;14) translocation mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9767530] Rothfels, Karen, 2022-02-28
name	FGFR3 805fs*141
referenceEntity	[ReferenceGeneProduct:403340] UniProt:P22607 FGFR3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1614387
startCoordinate	23

(hasMember)	[CandidateSet:R-HSA-2038374] FGFR3 (4;14) translocation mutants [plasma membrane]
(hasComponent)	[Complex:R-HSA-2038350] FGFR3 795fs*139STOP mutant dimer [plasma membrane]