Reactome | Palmitoylation of eNOS

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Palmitoylation of eNOS Show undefined attributes

authored	[InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
catalystActivity	[CatalystActivity:203709] protein-cysteine S-palmitoyltransferase activity of ZDHHC21 [Golgi membrane]
catalystActivityReference	[CatalystActivityReference:9911155] protein-cysteine S-palmitoyltransferase activity of ZDHHC21 [Golgi membrane] Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
category	transition
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
crossReference	[DatabaseIdentifier:9911164] RHEA:36684
dbId	203567
displayName	Palmitoylation of eNOS
eventOf	[Pathway:R-HSA-203615] eNOS activation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-203700] eNOS translocation from Golgi to Caveolae - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-203687] MyrG-NOS3 [cytosol] 2 × [SimpleEntity:R-ALL-200993] PALM-CoA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:203720] Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase [LiteratureReference:203698] Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling [LiteratureReference:203760] Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Palmitoylation of eNOS hexadecanoyl-CoA + L-cysteinyl-(protein) => CoA + S-hexadecanoyl-L-cysteinyl-(protein)
orthologousEvent	[Reaction:R-PFA-203567] Palmitoylation of eNOS - Plasmodium falciparum [Reaction:R-SCE-203567] Palmitoylation of eNOS - Saccharomyces cerevisiae [Reaction:R-SPO-203567] Palmitoylation of eNOS - Schizosaccharomyces pombe [Reaction:R-DDI-203567] Palmitoylation of eNOS - Dictyostelium discoideum [Reaction:R-DME-203567] Palmitoylation of eNOS - Drosophila melanogaster [Reaction:R-SSC-203567] Palmitoylation of eNOS - Sus scrofa [Reaction:R-BTA-203567] Palmitoylation of eNOS - Bos taurus [Reaction:R-RNO-203567] Palmitoylation of eNOS - Rattus norvegicus [Reaction:R-MMU-203567] Palmitoylation of eNOS - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-203769] 2xPalmC-MyrG-NOS3 [Golgi membrane] 2 × [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[Reaction:R-HSA-203611] N-myristoylation of eNOS - Homo sapiens [BlackBoxEvent:R-HSA-202132] depalmitoylated eNOS translocates from plasma membrane - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:215470] Enikolopov, G, 2008-02-28 17:52:44 [InstanceEdit:9917333] Hill, David P, 2024-08-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-203567
summation	[Summation:203741] ZDHHC21, associated with the Golgi membrane, palmitoylates c...
updateTrackers	[UpdateTracker:9919361] Update Tracker - [Reaction:203567] Palmitoylation of eNOS - v90:[modifyText, removeLiteratureReference, removeOutput] [UpdateTracker:9790427] Update Tracker - [Reaction:203567] palmitoylation of eNOS - v33:[addInput]

Referrals

(updatedInstance)	[UpdateTracker:9919361] Update Tracker - [Reaction:203567] Palmitoylation of eNOS - v90:[modifyText, removeLiteratureReference, removeOutput] [UpdateTracker:9790427] Update Tracker - [Reaction:203567] palmitoylation of eNOS - v33:[addInput]
(hasEvent)	[Pathway:R-HSA-203615] eNOS activation
(precedingEvent)	[BlackBoxEvent:R-HSA-203700] eNOS translocation from Golgi to Caveolae