Palmitoylation of eNOS

Stable Identifier
R-HSA-203567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
hexadecanoyl-CoA + L-cysteinyl-(protein) => CoA + S-hexadecanoyl-L-cysteinyl-(protein)
ReviewStatus
5/5
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ZDHHC21, associated with the Golgi membrane, palmitoylates cytosolic eNOS (Nitric oxide synthase 3), enabling its localization to plasmalemmal caveolae (Garcia-Cardena et al. 1996; Shaul et al. 1996). Localization to this microdomain is likely to optimize eNOS activation and the extracellular release of nitric oxide. ZDHHC21 belongs to a family of DHHC domain-containing cysteine-rich proteins, several of which can mediate eNOS palmitoylation in cultured human endothelial cells. Only inhibition of ZDHHC21 palmitoyl transferase reduces eNOS palmitoylation, eNOS targeting, and stimulated NO production (Fernández-Hernando et al. 2006), so only ZDHHC21 activity is annotated here.
Literature References
PubMed ID Title Journal Year
16864653 Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase

Sessa, WC, Bredt, DS, Bernatchez, PN, Fernandez-Hernando, C, Fukata, M, Lin, MI, Fukata, Y

J Cell Biol 2006
8626455 Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae

Michel, T, Robinson, LJ, Yuhanna, IS, Shaul, PW, German, Z, Smart, EJ, Anderson, RG, Ying, Y

J Biol Chem 1996
8692835 Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling

Schnitzer, JE, Liu, J, Sessa, WC, Garcia-Cardena, G, Oh, P

Proc Natl Acad Sci U S A 1996
Participants
Participates
Catalyst Activity

protein-cysteine S-palmitoyltransferase activity of ZDHHC21 [Golgi membrane]

Orthologous Events
Cross References
RHEA
Authored
Reviewed
Created
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