Reactome | palmitoylation of eNOS

palmitoylation of eNOS

Stable Identifier

R-HSA-203567

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

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DHHC-21 is a Golgi-localized acyl transferase that palmitoylates eNOS, which targets eNOS to plasmalemmal caveolae. Localization to this microdomain is likely to optimize eNOS activation and the extracellular release of nitric oxide.

Literature References

PubMed ID	Title	Journal	Year
16864653	Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase Sessa, WC, Bredt, DS, Bernatchez, PN, Fernandez-Hernando, C, Fukata, M, Lin, MI, Fukata, Y	J Cell Biol	2006
8692835	Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling Schnitzer, JE, Liu, J, Sessa, WC, Garcia-Cardena, G, Oh, P	Proc Natl Acad Sci U S A	1996