Reactome | Palmitoylation of eNOS

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Palmitoylation of eNOS Show undefined attributes

catalystActivity	[CatalystActivity:11006848] protein-cysteine S-palmitoyltransferase activity of ZDHHC21 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11006850
displayName	Palmitoylation of eNOS
eventOf	[Pathway:R-DDI-203615] eNOS activation - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DDI-203700] eNOS translocation from Golgi to Caveolae - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-203567] Palmitoylation of eNOS - Homo sapiens
input	[EntityWithAccessionedSequence:R-DDI-203687] MyrG-NOS3 [cytosol] 2 × [SimpleEntity:R-ALL-200993] PALM-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Palmitoylation of eNOS hexadecanoyl-CoA + L-cysteinyl-(protein) => CoA + S-hexadecanoyl-L-cysteinyl-(protein)
output	[EntityWithAccessionedSequence:R-DDI-203769] 2xPalmC-MyrG-NOS3 [Golgi membrane] 2 × [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[BlackBoxEvent:R-DDI-202132] depalmitoylated eNOS translocates from plasma membrane - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-203567
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-203615] eNOS activation
(inferredTo)	[Reaction:R-HSA-203567] Palmitoylation of eNOS
(precedingEvent)	[BlackBoxEvent:R-DDI-203700] eNOS translocation from Golgi to Caveolae

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