Reactome | FGFR2c mutants with enhanced ligand binding [plasma membrane]

Schema > CandidateSet > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2033472] FGFR2c mutants bind an expanded range of ligands - Homo sapiens
created	[InstanceEdit:2033376] Rothfels, K, 2012-01-09
dbId	2033375
disease	[Disease:1500689] cancer [Disease:1614674] female reproductive endometrioid cancer [Disease:1500575] ovarian cancer [Disease:2011822] acrocephalosyndactylia [Disease:2032940] bone development disease
displayName	FGFR2c mutants with enhanced ligand binding [plasma membrane]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-1637888] FGFR2c A314D [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1637889] FGFR2c A315T [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2071928] FGFR2c A314S [plasma membrane] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-2011852] FGFR2c S252W [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1637916] FGFR2c P253R [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2071931] FGFR2c A315S [plasma membrane] - Homo sapiens
inDisease	true
modified	[InstanceEdit:2071968] Rothfels, K, 2012-01-26
name	FGFR2c mutants with enhanced ligand binding
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2033375

(input)	[Reaction:R-HSA-2033472] FGFR2c mutants bind an expanded range of ligands
(diseaseEntity)	[EntityFunctionalStatus:5654520] gain_of_function of FGFR2c mutants with enhanced ligand binding [plasma membrane]