Reactome | FGFR2c mutants bind an expanded range of ligands

Schema > Reaction > Entries

FGFR2c mutants bind an expanded range of ligands Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2033473] Rothfels, K, 2012-01-09
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	2033472
disease	[Disease:1500689] cancer [Disease:1614674] female reproductive endometrioid cancer [Disease:1500575] ovarian cancer [Disease:2032940] bone development disease
displayName	FGFR2c mutants bind an expanded range of ligands
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654520] gain_of_function of FGFR2c mutants with enhanced ligand binding [plasma membrane]
eventOf	[Pathway:R-HSA-2033519] Activated point mutants of FGFR2 - Homo sapiens
followingEvent	[Reaction:R-HSA-2033486] Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding - Homo sapiens
input	[DefinedSet:R-HSA-2065982] FGFR2c mutant binding FGFs [extracellular region] 2 × [CandidateSet:R-HSA-2033375] FGFR2c mutants with enhanced ligand binding [plasma membrane] [SimpleEntity:R-ALL-190915] HS [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation [LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes [LiteratureReference:2029807] FGFR2 mutations are rare across histologic subtypes of ovarian cancer [LiteratureReference:2029802] Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities [LiteratureReference:2012014] Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome [LiteratureReference:1637876] Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome [LiteratureReference:2059901] Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome [LiteratureReference:2059894] Structural interactions of fibroblast growth factor receptor with its ligands
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FGFR2c mutants bind an expanded range of ligands
output	[Complex:R-HSA-2065986] FGFR2c mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2033472
summation	[Summation:2060302] Mutations in the highly conserved Pro-Ser dipeptide repeat o...

Referrals

(hasEvent)	[Pathway:R-HSA-2033519] Activated point mutants of FGFR2
(precedingEvent)	[Reaction:R-HSA-2033486] Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding