Reactome | Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity

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Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:2033451] protein tyrosine kinase activity of FGFR2 mutant dimers with enhanced kinase activity [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2033491] Rothfels, K, 2012-01-09
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	2033490
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654452] gain_of_function of FGFR2 mutant dimers with enhanced kinase activity [plasma membrane]
eventOf	[Pathway:R-HSA-2033519] Activated point mutants of FGFR2 - Homo sapiens
input	16 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [CandidateSet:R-HSA-2033349] FGFR2 mutant dimers with enhanced kinase activity [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation [LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes [LiteratureReference:2033243] A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases [LiteratureReference:2033246] Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis [LiteratureReference:2046359] Syndromic craniosynostosis: from history to hydrogen bonds [LiteratureReference:2032927] Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype [LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity
output	[CandidateSet:R-HSA-2033348] Activated FGFR2 mutants with enhanced kinase activity [plasma membrane] 16 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-2033479] Dimerization of FGFR2 point mutants with enhanced kinase activity - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2033490
summation	[Summation:2060754] Several missense mutations in the tyrosine kinase domain of ...

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(hasEvent)

[Pathway:R-HSA-2033519] Activated point mutants of FGFR2

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