Reactome | Autophosphorylation of PAK1

Autophosphorylation of PAK1

Stable Identifier

R-HSA-2029454

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PAK1 needs autophosphorylation for complete activation. PAK1 is autophosphorylated at several sites, but S144 flanking the kinase inhibitor region and T423 within the catalytic domain are the two conserved sites that regulate the catalytic activity (Chong et al. 2001, Parrini et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11804587	Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 Parrini, MC, Lei, M, Mayer, BJ, Harrison, SC	Mol Cell	2002
11278486	The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity Manser, E, Lim, L, Chong, C, Tan, L	J Biol Chem	2001