Cytosolic phospho-LATS2, complexed with MOB1, catalyzes the phosphorylation of YAP on serine residue 127 (and possibly other serine residues) (Zhao et al. 2007). This reaction is positively regulated by the angiomotin proteins AMOT (130 kd form), AMOTL1, and AMOTL2, which may function by physically bridging LATS2 and YAP (Paramasivam et al. 2011; Zhao et al. 2011).
Sarkeshik, A, Yates, JR 3rd, Paramasivam, M, McCollum, D, Fernandes, MJ
Lei, Q, Guan, KL, Liu, CY, Li, L, Wang, LH, Lu, Q, Zhao, B
Zheng, P, Halder, G, Ye, K, Lai, ZC, Yu, J, Wei, X, Guan, KL, Chinnaiyan, A, Xie, J, Yang, Q, Li, L, Kim, J, Li, W, Ikenoue, T, Udan, RS, Zhao, B
protein serine/threonine kinase activity of p-LATS2:p-MOB1 [cytosol]
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