Phosphorylation of YAP by LATS2

Stable Identifier
R-HSA-2028583
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic phospho-LATS2, complexed with MOB1, catalyzes the phosphorylation of YAP on serine residue 127 (and possibly other serine residues) (Zhao et al. 2007). This reaction is positively regulated by the angiomotin proteins AMOT (130 kd form), AMOTL1, and AMOTL2, which may function by physically bridging LATS2 and YAP (Paramasivam et al. 2011; Zhao et al. 2011).

Literature References
PubMed ID Title Journal Year
21205866 Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

Zhao, B, Li, L, Lu, Q, Wang, LH, Liu, CY, Lei, Q, Guan, KL

Genes Dev 2011
21832154 Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor

Paramasivam, M, Sarkeshik, A, Yates, JR 3rd, Fernandes, MJ, McCollum, D

Mol Biol Cell 2011
17974916 Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zhao, B, Wei, X, Li, W, Udan, RS, Yang, Q, Kim, J, Xie, J, Ikenoue, T, Yu, J, Li, L, Zheng, P, Ye, K, Chinnaiyan, A, Halder, G, Lai, ZC, Guan, KL

Genes Dev 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-LATS2:p-MOB1 [cytosol]
Physical Entity
Activity
This event is regulated
Positively by
Orthologous Events
Authored
Reviewed
Created
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