Reactome | Autocatalytic phosphorylation of FGFR1c P252X mutant dimers

Schema > Reaction > Entries

Autocatalytic phosphorylation of FGFR1c P252X mutant dimers Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:2023453] protein tyrosine kinase activity of FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2023454] Rothfels, K, 2011-12-07
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	2023455
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654445] gain_of_function of FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]
eventOf	[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1 - Homo sapiens
input	16 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2050638] FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2011820] Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
normalReaction	[Reaction:R-HSA-190429] Autocatalytic phosphorylation of FGFR1c
output	[Complex:R-HSA-2050642] Activated FGFR1c P252X mutants [plasma membrane] 16 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-2023451] FGFR1c P252X mutants bind ligand with enhanced affinity - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2023455
summation	[Summation:2023404] FGFR1 gain-of-function mutations at P252 that result in incr...

Referrals

(hasEvent)

[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1

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