Reactome | FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:2023453] protein tyrosine kinase activity of FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2023455] Autocatalytic phosphorylation of FGFR1c P252X mutant dimers - Homo sapiens
created	[InstanceEdit:2050637] Rothfels, K, 2012-01-11
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	2050638
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]
hasComponent	[DefinedSet:R-HSA-2050635] FGFR1c P252X mutant dimers [plasma membrane] 2 × [DefinedSet:R-HSA-189953] FGFR1c-binding FGFs [extracellular region] [SimpleEntity:R-ALL-190915] HS [extracellular region]
inDisease	true
includedLocation	[Compartment:984] extracellular region
isChimeric	false
maxDepth	4
modified	[InstanceEdit:9036004] Rothfels, Karen, 2018-01-26
name	FGFR1c P252X mutant dimers bound to FGFs
producedByEvent	[Reaction:R-HSA-2023451] FGFR1c P252X mutants bind ligand with enhanced affinity - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2050638
updateTrackers	[UpdateTracker:9893428] Update Tracker - [Complex:2050638] FGFR1c P252X mutant dimers bound to FGFs [plasma membrane] - v56:[updateContainedComponent] [UpdateTracker:9898542] Update Tracker - [Complex:2050638] FGFR1c P252X mutant dimers bound to FGFs [plasma membrane] - v64:[modifyName, updateContainedComponent]

(updatedInstance)	[UpdateTracker:9893428] Update Tracker - [Complex:2050638] FGFR1c P252X mutant dimers bound to FGFs [plasma membrane] - v56:[updateContainedComponent] [UpdateTracker:9898542] Update Tracker - [Complex:2050638] FGFR1c P252X mutant dimers bound to FGFs [plasma membrane] - v64:[modifyName, updateContainedComponent]
(output)	[Reaction:R-HSA-2023451] FGFR1c P252X mutants bind ligand with enhanced affinity
(input)	[Reaction:R-HSA-2023455] Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
(diseaseEntity)	[EntityFunctionalStatus:5654445] gain_of_function of FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]
(physicalEntity)	[CatalystActivity:2023453] protein tyrosine kinase activity of FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]