Reactome | Change of PKC theta conformation

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Change of PKC theta conformation Show undefined attributes

authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202370] protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
dbId	202307
displayName	Change of PKC theta conformation
eventOf	[Pathway:R-HSA-202424] Downstream TCR signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-202222] Phosphorylation of PKC theta - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-202187] PKC-theta (open): DAG [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202301] Selective function of PKC-theta in T cells [LiteratureReference:202369] Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Change of PKC theta conformation
orthologousEvent	[Reaction:R-SSC-202307] Change of PKC theta conformation - Sus scrofa [Reaction:R-BTA-202307] Change of PKC theta conformation - Bos taurus [Reaction:R-CFA-202307] Change of PKC theta conformation - Canis familiaris [Reaction:R-RNO-202307] Change of PKC theta conformation - Rattus norvegicus [Reaction:R-MMU-202307] Change of PKC theta conformation - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-202300] p-Y90-PKC-theta:DAG [plasma membrane]
precedingEvent	[Reaction:R-HSA-202328] Translocation of PKC theta to plasma membrane - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202307
summation	[Summation:203255] PKC theta localizes at the interface between T cells and ant...

Referrals

(hasEvent)	[Pathway:R-HSA-202424] Downstream TCR signaling
(precedingEvent)	[Reaction:R-HSA-202222] Phosphorylation of PKC theta

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