Change of PKC theta conformation

Stable Identifier
R-HSA-202307
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Change of PKC theta conformation
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PKC theta localizes at the interface between T cells and antigen presenting cells. Upon the T cell activation and release of the second messengers Ca++ and DAG by PLC-gamma1, DAG binds to the C1 domain of the PKC theta thereby enhances the attachment to the plasma membrane. Upon membrane translocation, PKC theta is phosphorylated at tyrosine 90 in the C2 like domain. This phosphorylation is mediated by the tyrosine kinase Lck. These association and, most likely, other regulatory interactions, lead to a change in PKC theta conformation into an open, active state whereby it can now access its substrates and phosphorylate them.

Literature References
PubMed ID Title Journal Year
12473184 Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death

Altman, A, Villalba, M

J Biochem (Tokyo) 2002
16978534 Selective function of PKC-theta in T cells

Manicassamy, S, Gupta, S, Sun, Z

Cell Mol Immunol 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
Physical Entity
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Change of PKC theta conformation (Bos taurus)
Change of PKC theta conformation (Canis familiaris)
Change of PKC theta conformation (Mus musculus)
Change of PKC theta conformation (Rattus norvegicus)
Change of PKC theta conformation (Sus scrofa)
Change of PKC theta conformation (Xenopus tropicalis)
Authored
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Garapati, P V  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-29)