Reactome | CS-GAG biosynthesis

CS-GAG biosynthesis

Stable Identifier

R-HSA-2022870

Type

Pathway

Species

Homo sapiens

Synonyms

Chondroitin sulfate biosynthesis

ReviewStatus

5/5

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Chondroitin sulfate (CS) glycosaminoglycan chains consist of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA). They are bound to the tetrasaccharide linker moiety of core proteins like aggrecan, versican, or decorin. GalNAc residues are sulfated to varying degrees on 4- and/or 6- positions. The steps below describe the biosynthesis of a simple CS chain on a set of possible core proteins (reviewed in Pavao et al. 2006; Silbert & Sugumaran 2002; Mikami & Kitagawa, 2013; Nowicka & Gręda, 2019).

Literature References

PubMed ID	Title	Journal	Year
17239764	Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetics approaches Pavão, MS, Vilela-Silva, AC, Mourão, PA	Adv Pharmacol	2006
12512856	Biosynthesis of chondroitin/dermatan sulfate Silbert, JE, Sugumaran, G	IUBMB Life	2002
31885391	Chondroitin sulfate metabolism in the brain Nowicka, D, Gręda, A	Acta Neurobiol Exp (Wars)	2019
23774590	Biosynthesis and function of chondroitin sulfate Mikami, T, Kitagawa, H	Biochim Biophys Acta	2013