Chondroitin sulfate biosynthesis

Stable Identifier
R-HSA-2022870
Type
Pathway
Species
Homo sapiens
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Chondroitin sulfate (CS) glycosaminoglycan consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA). GalNAc residues are sulfated to varying degrees on 4- and/or 6- positions. The steps below describe the biosynthesis of a simple CS molecule (Pavao et al. 2006, Silbert & Sugumaran 2002).

Literature References
PubMed ID Title Journal Year
17239764 Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetics approaches

Mourão, PA, Pavão, MS, Vilela-Silva, AC

Adv Pharmacol 2006
12512856 Biosynthesis of chondroitin/dermatan sulfate

Sugumaran, G, Silbert, JE

IUBMB Life 2002
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GlyCosmos
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