Chondroitin sulfate biosynthesis

Stable Identifier
R-HSA-2022870
Type
Pathway
Species
Homo sapiens
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Chondroitin sulfate biosynthesis
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Chondroitin sulfate (CS) glycosaminoglycan consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA). GalNAc residues are sulfated to varying degrees on 4- and/or 6- positions. The steps below describe the biosynthesis of a simple CS molecule (Pavao et al. 2006, Silbert & Sugumaran 2002).

Literature References
PubMed ID Title Journal Year
12512856 Biosynthesis of chondroitin/dermatan sulfate

Silbert, JE, Sugumaran, G

IUBMB Life 2002
17239764 Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetics approaches

Pavão, MS, Vilela-Silva, AC, Mourão, PA

Adv Pharmacol 2006
Participants
Events
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Event Information
Go Biological Process
chondroitin sulfate biosynthetic process (0030206)
Orthologous Events
Chondroitin sulfate biosynthesis (Bos taurus)
Chondroitin sulfate biosynthesis (Canis familiaris)
Chondroitin sulfate biosynthesis (Danio rerio)
Chondroitin sulfate biosynthesis (Drosophila melanogaster)
Chondroitin sulfate biosynthesis (Gallus gallus)
Chondroitin sulfate biosynthesis (Mus musculus)
Chondroitin sulfate biosynthesis (Rattus norvegicus)
Chondroitin sulfate biosynthesis (Sus scrofa)
Chondroitin sulfate biosynthesis (Xenopus tropicalis)
Authored
Jassal, B  (2011-12-01)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-12-01)