Reactome | EXT1:EXT2 transfers GlcNAc to the heparan chain

Schema > Reaction > Entries

EXT1:EXT2 transfers GlcNAc to the heparan chain Show undefined attributes

authored	[InstanceEdit:2022912] Jassal, B, 2011-12-01
catalystActivity	[CatalystActivity:2022845] glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity of EXT1:EXT2 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:2022912] Jassal, B, 2011-12-01
crossReference	[DatabaseIdentifier:9941329] RHEA:16214
dbId	2022851
diseaseReaction	[FailedReaction:R-HSA-3656254] Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain - Homo sapiens [FailedReaction:R-HSA-3656261] Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain - Homo sapiens
displayName	EXT1:EXT2 transfers GlcNAc to the heparan chain
edited	[InstanceEdit:2022912] Jassal, B, 2011-12-01
eventOf	[Pathway:R-HSA-2022928] HS-GAG biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2076392] EXT1:EXT2 transfers GlcA to heparan - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:19668] heparan sulfate proteoglycan biosynthetic process
input	[DefinedSet:R-HSA-2076416] Heparan(1)-PGs [Golgi lumen] [SimpleEntity:R-ALL-914003] UDP-GlcNAc [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2022877] Diminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytes [LiteratureReference:2022859] Mutations in the EXT1 and EXT2 genes in hereditary multiple exostoses [LiteratureReference:2022914] The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	EXT1:EXT2 transfers GlcNAc to the heparan chain Another GlcNAc addition extends the heparan chain
orthologousEvent	[Reaction:R-BTA-2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain - Bos taurus [Reaction:R-DME-2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain - Drosophila melanogaster [Reaction:R-DRE-2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain - Danio rerio [Reaction:R-SSC-2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain - Sus scrofa [Reaction:R-CFA-2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain - Canis familiaris [Reaction:R-RNO-2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain - Rattus norvegicus [Reaction:R-MMU-2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain - Mus musculus
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [DefinedSet:R-HSA-2076412] Heparan(2)-PGs [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-2022856] EXT1:EXT2 transfers GlcA to heparan - Homo sapiens [Reaction:R-HSA-741450] SLC35A3 exchanges UDP-GlcNAc for UMP - Homo sapiens [Reaction:R-HSA-742354] SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen - Homo sapiens [Reaction:R-HSA-744231] SLC35D2 exchanges UDP-GlcNAc for UMP - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2022851
summation	[Summation:2022898] The EXT2 subunit of the EXT1:EXT2 complex transfers an N-ace...
updateTrackers	[UpdateTracker:9786262] Update Tracker - [Reaction:2022851] EXT1:EXT2 transfer GlcNAc to the heparan chain - v50:[modifyText] [UpdateTracker:9953677] Update Tracker - [Reaction:2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain - v93:[modifyText, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9786262] Update Tracker - [Reaction:2022851] EXT1:EXT2 transfer GlcNAc to the heparan chain - v50:[modifyText] [UpdateTracker:9953677] Update Tracker - [Reaction:2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain - v93:[modifyText, removeOutput]
(normalReaction)	[FailedReaction:R-HSA-3656254] Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain [FailedReaction:R-HSA-3656261] Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain
(hasEvent)	[Pathway:R-HSA-2022928] HS-GAG biosynthesis
(precedingEvent)	[Reaction:R-HSA-2076392] EXT1:EXT2 transfers GlcA to heparan

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