Reactome | Phosphorylation of TBSMs in LAT

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Phosphorylation of TBSMs in LAT Show undefined attributes

catalystActivity	[CatalystActivity:10245241] protein tyrosine kinase activity of Activated ZAP-70 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10245243
displayName	Phosphorylation of TBSMs in LAT
eventOf	[Pathway:R-CFA-202433] Generation of second messenger molecules - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-202212] Recruitment of PLC-gamma1 to LAT - Canis familiaris [Reaction:R-CFA-202325] Recruitment of Gads to LAT - Canis familiaris
inferredFrom	[Reaction:R-HSA-202245] Phosphorylation of TBSMs in LAT - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-CFA-202322] LAT [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of TBSMs in LAT
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-CFA-202364] phospho-LAT [plasma membrane]
precedingEvent	[Reaction:R-CFA-202174] Activation of ZAP-70 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-202245
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-202433] Generation of second messenger molecules
(precedingEvent)	[Reaction:R-CFA-202212] Recruitment of PLC-gamma1 to LAT [Reaction:R-CFA-202325] Recruitment of Gads to LAT
(inferredTo)	[Reaction:R-HSA-202245] Phosphorylation of TBSMs in LAT

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