Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)

Stable Identifier
Reaction [transition]
Homo sapiens
Cathepsin G Hydrolyzes Angiotensin I to Yield Angiotensin II
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Cathepsin G hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Reilly et al. 1982, Owen and Campbell 1998, Raymond et al. 2010). Cathepsin bound to the plasma membrane of neutrophils has a higher activity than does soluble cathepsin G (Owen and Campbell 1998).

Literature References
PubMed ID Title Journal Year
20889553 How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution

Raymond, WW, Ray, M, Makarova, A, Trivedi, NN, Caughey, GH, Craik, CS

J Immunol 2010
9570564 Angiotensin II generation at the cell surface of activated neutrophils: novel cathepsin G-mediated catalytic activity that is resistant to inhibition

Owen, CA, Campbell, EJ

J Immunol 1998
6807977 Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases

Reilly, CF, Travis, J, Schechter, NM, Tewksbury, DA

J Biol Chem 1982
Event Information
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Catalyst Activity

serine-type endopeptidase activity of Cathepsin G [plasma membrane]

Orthologous Events
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