Cathepsin G hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Reilly et al. 1982, Owen and Campbell 1998, Raymond et al. 2010). Cathepsin bound to the plasma membrane of neutrophils has a higher activity than does soluble cathepsin G (Owen and Campbell 1998).
Raymond, WW, Ray, M, Makarova, A, Trivedi, NN, Caughey, GH, Craik, CS
Owen, CA, Campbell, EJ
Reilly, CF, Travis, J, Schechter, NM, Tewksbury, DA
serine-type endopeptidase activity of Cathepsin G [plasma membrane]
© 2022 Reactome