Reactome | Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

Stable Identifier

R-HSA-2022411

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Cathepsin G Hydrolyzes Angiotensin I to Yield Angiotensin II

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cathepsin G hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Reilly et al. 1982, Owen and Campbell 1998, Raymond et al. 2010). Cathepsin bound to the plasma membrane of neutrophils has a higher activity than does soluble cathepsin G (Owen and Campbell 1998).

Literature References

PubMed ID	Title	Journal	Year
20889553	How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution Raymond, WW, Trivedi, NN, Makarova, A, Ray, M, Craik, CS, Caughey, GH	J Immunol	2010
9570564	Angiotensin II generation at the cell surface of activated neutrophils: novel cathepsin G-mediated catalytic activity that is resistant to inhibition Owen, CA, Campbell, EJ	J Immunol	1998
6807977	Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases Reilly, CF, Tewksbury, DA, Schechter, NM, Travis, J	J Biol Chem	1982