Reactome | Dephosphorylation of Lck-pY505 by CD45

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Dephosphorylation of Lck-pY505 by CD45 Show undefined attributes

authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202295] protein tyrosine phosphatase activity of CD45,CD148 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
dbId	202214
displayName	Dephosphorylation of Lck-pY505 by CD45
eventOf	[Pathway:R-HSA-202427] Phosphorylation of CD3 and TCR zeta chains - Homo sapiens
followingEvent	[Reaction:R-HSA-202291] Activation of Lck - Homo sapiens
input	[Complex:R-HSA-202154] Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6785299] Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines [LiteratureReference:6785272] CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development [LiteratureReference:6785262] Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148 [LiteratureReference:202347] Adapters in lymphocyte signaling [LiteratureReference:6785301] The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Dephosphorylation of Lck-pY505 by CD45
orthologousEvent	[Reaction:R-SSC-202214] Dephosphorylation of Lck-pY505 by CD45 - Sus scrofa [Reaction:R-BTA-202214] Dephosphorylation of Lck-pY505 by CD45 - Bos taurus [Reaction:R-CFA-202214] Dephosphorylation of Lck-pY505 by CD45 - Canis familiaris [Reaction:R-RNO-202214] Dephosphorylation of Lck-pY505 by CD45 - Rattus norvegicus [Reaction:R-MMU-202214] Dephosphorylation of Lck-pY505 by CD45 - Mus musculus
output	[Complex:R-HSA-202157] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-202233] Inactivation of Lck by Csk - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202214
summation	[Summation:202230] TCR stimulation induce the transient dephosphorylation of PA...
updateTrackers	[UpdateTracker:9784384] Update Tracker - [Reaction:202214] Dephosphorylation of Lck-pY505 by CD45 - v54:[addLiteratureReference, modifyText] [UpdateTracker:9790864] Update Tracker - [Reaction:202214] Dephosphorylation of Lck-pY505 by CD45 - v32:[add_removeOutput] [UpdateTracker:9953746] Update Tracker - [Reaction:202214] Dephosphorylation of Lck-pY505 by CD45 - v93:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784384] Update Tracker - [Reaction:202214] Dephosphorylation of Lck-pY505 by CD45 - v54:[addLiteratureReference, modifyText] [UpdateTracker:9790864] Update Tracker - [Reaction:202214] Dephosphorylation of Lck-pY505 by CD45 - v32:[add_removeOutput] [UpdateTracker:9953746] Update Tracker - [Reaction:202214] Dephosphorylation of Lck-pY505 by CD45 - v93:[modifyText]
(hasEvent)	[Pathway:R-HSA-202427] Phosphorylation of CD3 and TCR zeta chains
(precedingEvent)	[Reaction:R-HSA-202291] Activation of Lck

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