Reactome | Inactivation of Lck by Csk

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Inactivation of Lck by Csk Show undefined attributes

authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202267] protein tyrosine kinase activity of Csk:p-PAG [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
dbId	202233
displayName	Inactivation of Lck by Csk
eventOf	[Pathway:R-HSA-202427] Phosphorylation of CD3 and TCR zeta chains - Homo sapiens
followingEvent	[Reaction:R-HSA-202214] Dephosphorylation of Lck-pY505 by CD45 - Homo sapiens
input	[Complex:R-HSA-202157] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202290] Structure and regulation of Src family kinases [LiteratureReference:202415] Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Inactivation of Lck by Csk
orthologousEvent	[Reaction:R-XTR-202233] Inactivation of Lck by Csk - Xenopus tropicalis [Reaction:R-SSC-202233] Inactivation of Lck by Csk - Sus scrofa [Reaction:R-BTA-202233] Inactivation of Lck by Csk - Bos taurus [Reaction:R-CFA-202233] Inactivation of Lck by Csk - Canis familiaris [Reaction:R-RNO-202233] Inactivation of Lck by Csk - Rattus norvegicus [Reaction:R-MMU-202233] Inactivation of Lck by Csk - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-202154] Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane]
precedingEvent	[Reaction:R-HSA-203774] Interaction of Csk with PAG - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-6785250] Negative regulation by 'CD45,CD148 [plasma membrane]'
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202233
summation	[Summation:202194] Lck is a member of the Src family tyrosine kinases and these... [Summation:6785258] Protein tyrosine phosphatase CD45 (PTPRC) and CD148 (PTPRJ) ...
updateTrackers	[UpdateTracker:9784477] Update Tracker - [Reaction:202233] Inactivation of Lck by Csk - v54:[addRegulator] [UpdateTracker:9775677] Update Tracker - [Reaction:202233] Inactivation of Lck by Csk - v78:[addSummation]

Referrals

(updatedInstance)	[UpdateTracker:9784477] Update Tracker - [Reaction:202233] Inactivation of Lck by Csk - v54:[addRegulator] [UpdateTracker:9775677] Update Tracker - [Reaction:202233] Inactivation of Lck by Csk - v78:[addSummation]
(hasEvent)	[Pathway:R-HSA-202427] Phosphorylation of CD3 and TCR zeta chains
(precedingEvent)	[Reaction:R-HSA-202214] Dephosphorylation of Lck-pY505 by CD45