Reactome | Dephosphorylation of Lck-pY505 by CD45

Schema > Reaction > Entries

Dephosphorylation of Lck-pY505 by CD45 Show undefined attributes

catalystActivity	[CatalystActivity:10466884] protein tyrosine phosphatase activity of CD45,CD148 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10466886
displayName	Dephosphorylation of Lck-pY505 by CD45
eventOf	[Pathway:R-SSC-202427] Phosphorylation of CD3 and TCR zeta chains - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-202291] Activation of Lck - Sus scrofa
inferredFrom	[Reaction:R-HSA-202214] Dephosphorylation of Lck-pY505 by CD45 - Homo sapiens
input	[Complex:R-SSC-202154] Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Dephosphorylation of Lck-pY505 by CD45
output	[Complex:R-SSC-202157] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-SSC-202233] Inactivation of Lck by Csk - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-202214
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-202427] Phosphorylation of CD3 and TCR zeta chains
(precedingEvent)	[Reaction:R-SSC-202291] Activation of Lck
(inferredTo)	[Reaction:R-HSA-202214] Dephosphorylation of Lck-pY505 by CD45

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