Reactome | PARP1 [nucleoplasm]

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PARP1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9677228] NP:PARP1 [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-4551768] PIAS4 SUMOylates PARP1 with SUMO2,3 - Homo sapiens [Reaction:R-HSA-4551604] PIAS4 SUMOylates PARP1 with SUMO1 - Homo sapiens [Reaction:R-HSA-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Homo sapiens
created	[InstanceEdit:201610] Matthews, L, 2007-09-03 08:36:41
dbId	201568
displayName	PARP1 [nucleoplasm]
endCoordinate	1014
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-201568] PARP1 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-201568] PARP1 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-201568] PARP1 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-201568] PARP1 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-201568] PARP1 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-201568] PARP1 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-201568] parp1 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-201568] PARP1 [nucleoplasm] - Gallus gallus [GenomeEncodedEntity:R-DME-201568] Ghost homologue of PARP1 [nucleoplasm] - Drosophila melanogaster [GenomeEncodedEntity:R-CEL-201568] Ghost homologue of PARP1 [nucleoplasm] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-201568] PARP1 [nucleoplasm] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-201568-2] adprt1B [nucleoplasm] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-201568-3] adprt1A [nucleoplasm] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-201568-4] adprt4 [nucleoplasm] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-201568-5] adprt2 [nucleoplasm] - Dictyostelium discoideum [DefinedSet:R-DDI-201568-6] Homologues of PARP1 [nucleoplasm] - Dictyostelium discoideum
maxDepth	1
memberOf	[CandidateSet:R-HSA-5649876] PARP1,PARP2 [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:2187331] Orlic-Milacic, M, 2012-04-09
name	PARP1 Poly (ADP-ribose) polymerase 1
producedByEvent	[Reaction:R-HSA-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4 - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P09874] UniProt:P09874 PARP1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-201568
startCoordinate	2

Referrals

(input)	[Reaction:R-HSA-4551768] PIAS4 SUMOylates PARP1 with SUMO2,3 [Reaction:R-HSA-4551604] PIAS4 SUMOylates PARP1 with SUMO1 [Reaction:R-HSA-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer
(hasMember)	[CandidateSet:R-HSA-5649876] PARP1,PARP2 [nucleoplasm]
(hasComponent)	[Complex:R-HSA-9677228] NP:PARP1 [nucleoplasm] [Complex:R-HSA-2187322] p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm]
(output)	[Reaction:R-HSA-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4
(activeUnit)	[CatalystActivity:2187313] NAD+ poly-ADP-ribosyltransferase activity of p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm]

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