Reactome | PARP1 ADP-ribosylates SMAD3 and SMAD4

Schema > Reaction > Entries

PARP1 ADP-ribosylates SMAD3 and SMAD4 Show undefined attributes

authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
catalystActivity	[CatalystActivity:2187313] NAD+ poly-ADP-ribosyltransferase activity of p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2187320] Orlic-Milacic, M, 2012-04-09
dbId	2187325
displayName	PARP1 ADP-ribosylates SMAD3 and SMAD4
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens
input	[SimpleEntity:R-ALL-427523] NAD+ [nucleoplasm] [Complex:R-HSA-2187322] p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2187315] PARP-1 attenuates Smad-mediated transcription
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PARP1 ADP-ribosylates SMAD3 and SMAD4
orthologousEvent	[Reaction:R-GGA-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4 - Gallus gallus [Reaction:R-XTR-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4 - Xenopus tropicalis [Reaction:R-SSC-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4 - Sus scrofa [Reaction:R-BTA-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4 - Bos taurus [Reaction:R-CFA-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4 - Canis familiaris [Reaction:R-RNO-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4 - Rattus norvegicus [Reaction:R-MMU-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4 - Mus musculus
output	[SimpleEntity:R-ALL-427497] NAM [nucleoplasm] [DefinedSet:R-HSA-2187328] PAR-SMAD2,3:PAR-SMAD4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-201568] PARP1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2187325
summation	[Summation:2187318] PARP1 ADP-ribosylates SMAD3 and SMAD4 in SMAD2/3:SMAD4 heter...

Referrals

(hasEvent)	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(precedingEvent)	[NegativePrecedingEvent:9754407] Futile Cycle: PARP1 ADP-ribosylates SMAD3 and SMAD4