Reactome | Activated type I receptor phosphorylates R-Smad1/5/8 directly

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Activated type I receptor phosphorylates R-Smad1/5/8 directly Show undefined attributes

authored	[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00
catalystActivity	[CatalystActivity:201437] transmembrane receptor protein serine/threonine kinase activity of BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05
dbId	201476
displayName	Activated type I receptor phosphorylates R-Smad1/5/8 directly
eventOf	[Pathway:R-HSA-201451] Signaling by BMP - Homo sapiens
followingEvent	[Reaction:R-HSA-201453] Phospho-R-Smad1/5/8 dissociates from the receptor complex - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-201477] BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202605] The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase [LiteratureReference:202620] MADR1, a MAD-related protein that functions in BMP2 signaling pathways
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Activated type I receptor phosphorylates R-Smad1/5/8 directly
orthologousEvent	[Reaction:R-CFA-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - Canis familiaris [Reaction:R-DME-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - Drosophila melanogaster [Reaction:R-GGA-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - Gallus gallus [Reaction:R-XTR-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - Xenopus tropicalis [Reaction:R-DRE-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - Danio rerio [Reaction:R-SSC-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - Sus scrofa [Reaction:R-BTA-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - Bos taurus [Reaction:R-RNO-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - Rattus norvegicus [Reaction:R-MMU-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-201467] BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane]
precedingEvent	[Reaction:R-HSA-201648] An anchoring protein, Endofin, recruits R-Smad1/5/8 - Homo sapiens
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:203122] Heldin, CH, 2007-11-12
revised	[InstanceEdit:9635710] Mi, Huaiyu, 2019-02-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-201476
summation	[Summation:176013] Activated type I receptor kinase directly phosphorylates two...
updateTrackers	[UpdateTracker:9788948] Update Tracker - [Reaction:201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - v39:[modifyText] [UpdateTracker:9777089] Update Tracker - [Reaction:201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - v72:[modifyText] [UpdateTracker:9789112] Update Tracker - [Reaction:201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - v38:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788948] Update Tracker - [Reaction:201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - v39:[modifyText] [UpdateTracker:9777089] Update Tracker - [Reaction:201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - v72:[modifyText] [UpdateTracker:9789112] Update Tracker - [Reaction:201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - v38:[modifyText]
(hasEvent)	[Pathway:R-HSA-201451] Signaling by BMP
(precedingEvent)	[Reaction:R-HSA-201453] Phospho-R-Smad1/5/8 dissociates from the receptor complex

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