Reactome | Activated type I receptor phosphorylates R-Smad1/5/8 directly

Activated type I receptor phosphorylates R-Smad1/5/8 directly

Stable Identifier

R-HSA-201476

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Activated type I receptor phosphorylates R-Smad1/5/8 directly

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Activated type I receptor kinase directly phosphorylates two of the C-terminal serine residues of SMAD1, SMAD5 or SMAD8. Binding of these R-SMADs to the L45 loop of the type I receptor is critical for this event.

Literature References

PubMed ID	Title	Journal	Year
8653785	MADR1, a MAD-related protein that functions in BMP2 signaling pathways Hoodless, PA, Haerry, T, Abdollah, S, Stapleton, M, O'Connor, MB, Attisano, L, Wrana, JL	Cell	1996
9136927	The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase Kretzschmar, M, Liu, F, Hata, A, Doody, J, Massague, J	Genes Dev	1997