Reactome | Activated type I receptor phosphorylates R-Smad1/5/8 directly

Activated type I receptor phosphorylates R-Smad1/5/8 directly

Stable Identifier

R-HSA-201476

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Activated type I receptor phosphorylates R-Smad1/5/8 directly

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated type I receptor kinase directly phosphorylates two of the C-terminal serine residues of SMAD1, SMAD5 or SMAD8. Binding of these R-SMADs to the L45 loop of the type I receptor is critical for this event.

Literature References

PubMed ID	Title	Journal	Year
8653785	MADR1, a MAD-related protein that functions in BMP2 signaling pathways Wrana, JL, O'Connor, MB, Stapleton, M, Attisano, L, Abdollah, S, Haerry, T, Hoodless, PA	Cell	1996
9136927	The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase Massague, J, Kretzschmar, M, Doody, J, Liu, F, Hata, A	Genes Dev	1997