Reactome | Activated type I receptor phosphorylates R-Smad1/5/8 directly

Schema > Reaction > Entries

Activated type I receptor phosphorylates R-Smad1/5/8 directly Show undefined attributes

catalystActivity	[CatalystActivity:10244588] transmembrane receptor protein serine/threonine kinase activity of BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10244590
displayName	Activated type I receptor phosphorylates R-Smad1/5/8 directly
eventOf	[Pathway:R-CFA-201451] Signaling by BMP - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-201453] Phospho-R-Smad1/5/8 dissociates from the receptor complex - Canis familiaris
inferredFrom	[Reaction:R-HSA-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-201477] BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated type I receptor phosphorylates R-Smad1/5/8 directly
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-201467] BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane]
precedingEvent	[Reaction:R-CFA-201648] An anchoring protein, Endofin, recruits R-Smad1/5/8 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-201476
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-201451] Signaling by BMP
(precedingEvent)	[Reaction:R-CFA-201453] Phospho-R-Smad1/5/8 dissociates from the receptor complex
(inferredTo)	[Reaction:R-HSA-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly

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