Reactome | Removal of fibrillar collagen C-propeptides

Schema > Reaction > Entries

Removal of fibrillar collagen C-propeptides Show undefined attributes

authored	[InstanceEdit:913966] Jupe, S, 2010-07-20
catalystActivity	[CatalystActivity:2002398] metalloendopeptidase activity of Procollagen C-proteinases [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:2002388] Jupe, S, 2011-11-21
dbId	2002440
displayName	Removal of fibrillar collagen C-propeptides
edited	[InstanceEdit:2247551] Jupe, S, 2012-05-14
eventOf	[Pathway:R-HSA-1650814] Collagen biosynthesis and modifying enzymes - Homo sapiens
followingEvent	[Polymerisation:R-HSA-1474266] Formation of collagen fibrils - Homo sapiens
input	[DefinedSet:R-HSA-2268931] Fibrillar procollagens -N [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2002424] Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis [LiteratureReference:2247896] Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Removal of fibrillar collagen C-propeptides
orthologousEvent	[Reaction:R-CEL-2002440] Removal of fibrillar collagen C-propeptides - Caenorhabditis elegans [Reaction:R-DME-2002440] Removal of fibrillar collagen C-propeptides - Drosophila melanogaster [Reaction:R-DRE-2002440] Removal of fibrillar collagen C-propeptides - Danio rerio [Reaction:R-SSC-2002440] Removal of fibrillar collagen C-propeptides - Sus scrofa [Reaction:R-BTA-2002440] Removal of fibrillar collagen C-propeptides - Bos taurus [Reaction:R-CFA-2002440] Removal of fibrillar collagen C-propeptides - Canis familiaris [Reaction:R-RNO-2002440] Removal of fibrillar collagen C-propeptides - Rattus norvegicus [Reaction:R-MMU-2002440] Removal of fibrillar collagen C-propeptides - Mus musculus
output	[DefinedSet:R-HSA-2060921] Tropocollagens [extracellular region]
precedingEvent	[Reaction:R-HSA-2002428] Removal of fibrillar collagen N-propeptides - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-2267335] Positive regulation by 'PCOLCEs [extracellular region]'
regulationReference	[RegulationReference:9641790] Positive regulation by 'PCOLCEs [extracellular region]' PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2267224] Canty-Laird, EG, 2012-05-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2002440
summation	[Summation:2002400] Fibrillar collagen is synthesized in the ER as procollagen w...

Referrals

(hasEvent)	[Pathway:R-HSA-1650814] Collagen biosynthesis and modifying enzymes
(precedingEvent)	[Polymerisation:R-HSA-1474266] Formation of collagen fibrils