Reactome | Collagen biosynthesis and modifying enzymes

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Collagen biosynthesis and modifying enzymes Show undefined attributes

authored	[InstanceEdit:913966] Jupe, S, 2010-07-20
created	[InstanceEdit:1650793] Jupe, S, 2011-10-12
dbId	1650814
displayName	Collagen biosynthesis and modifying enzymes
doi	10.3180/REACT_121139.1
edited	[InstanceEdit:2247551] Jupe, S, 2012-05-14
eventOf	[Pathway:R-HSA-1474290] Collagen formation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20746] collagen fibril organization
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-2002460] P4HB binds Collagen chains - Homo sapiens [Reaction:R-HSA-1650808] Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines - Homo sapiens [BlackBoxEvent:R-HSA-8948234] P4HB:4-Hyp collagen propeptides dissociates - Homo sapiens [Reaction:R-HSA-8948230] P3HB binds 4-Hyp-collagen propeptides - Homo sapiens [Reaction:R-HSA-1980233] Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen - Homo sapiens [BlackBoxEvent:R-HSA-8948226] Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates - Homo sapiens [Reaction:R-HSA-1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines - Homo sapiens [BlackBoxEvent:R-HSA-8948232] Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases - Homo sapiens [Reaction:R-HSA-8948228] COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides - Homo sapiens [Reaction:R-HSA-8948219] PLOD3 binds Lysyl hydroxylated collagen propeptides - Homo sapiens [Reaction:R-HSA-1981120] Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. - Homo sapiens [Reaction:R-HSA-1981128] Galactosylation of collagen propeptide hydroxylysines by PLOD3 - Homo sapiens [BlackBoxEvent:R-HSA-8948231] COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates - Homo sapiens [BlackBoxEvent:R-HSA-8948222] PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates - Homo sapiens [Reaction:R-HSA-1981157] Glucosylation of collagen propeptide hydroxylysines - Homo sapiens [BlackBoxEvent:R-HSA-8948224] PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates - Homo sapiens [Pathway:R-HSA-8948216] Collagen chain trimerization - Homo sapiens [Reaction:R-HSA-2022073] Procollagen triple helix formation - Homo sapiens [Reaction:R-HSA-1614460] Dimerization of procollagen type VI - Homo sapiens [Reaction:R-HSA-1614461] Tetramerization of procollagen VI - Homo sapiens [BlackBoxEvent:R-HSA-2089971] Secretion of collagens - Homo sapiens [BlackBoxEvent:R-HSA-2152276] Secretion of transmembrane collagens - Homo sapiens [Reaction:R-HSA-2002428] Removal of fibrillar collagen N-propeptides - Homo sapiens [Reaction:R-HSA-2002440] Removal of fibrillar collagen C-propeptides - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2172404] Collagens at a glance [LiteratureReference:1637778] Collagens, modifying enzymes and their mutations in humans, flies and worms
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	Collagen biosynthesis and modifying enzymes
orthologousEvent	[Pathway:R-DDI-1650814] Collagen biosynthesis and modifying enzymes - Dictyostelium discoideum [Pathway:R-CEL-1650814] Collagen biosynthesis and modifying enzymes - Caenorhabditis elegans [Pathway:R-DME-1650814] Collagen biosynthesis and modifying enzymes - Drosophila melanogaster [Pathway:R-GGA-1650814] Collagen biosynthesis and modifying enzymes - Gallus gallus [Pathway:R-XTR-1650814] Collagen biosynthesis and modifying enzymes - Xenopus tropicalis [Pathway:R-DRE-1650814] Collagen biosynthesis and modifying enzymes - Danio rerio [Pathway:R-SSC-1650814] Collagen biosynthesis and modifying enzymes - Sus scrofa [Pathway:R-BTA-1650814] Collagen biosynthesis and modifying enzymes - Bos taurus [Pathway:R-CFA-1650814] Collagen biosynthesis and modifying enzymes - Canis familiaris [Pathway:R-RNO-1650814] Collagen biosynthesis and modifying enzymes - Rattus norvegicus [Pathway:R-MMU-1650814] Collagen biosynthesis and modifying enzymes - Mus musculus
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2267224] Canty-Laird, EG, 2012-05-24
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1650814
summation	[Summation:1650785] The biosynthesis of collagen is a multistep process. Collage...

Referrals

(hasEvent)

[Pathway:R-HSA-1474290] Collagen formation

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