Reactome | p-6Y-EGFR K739_I744dup [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p-6Y-EGFR K739_I744dup [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-1182982] Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1996345] Orlic-Milacic, Marija, 2011-11-19
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233 [DatabaseIdentifier:9831582] COSMIC:COSM53176
dbId	1996346
disease	[Disease:1500689] cancer [Disease:1500699] lung cancer [Disease:1247848] non-small cell lung carcinoma
displayName	p-6Y-EGFR K739_I744dup [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[FragmentInsertionModification:1996307] Insertion of residues 739 to 744 at 745 from UniProt:P00533 EGFR [ModifiedResidue:182927] O4'-phospho-L-tyrosine at 1069 [ModifiedResidue:179797] O4'-phospho-L-tyrosine at 1092 [ModifiedResidue:179834] O4'-phospho-L-tyrosine at 1110 [ModifiedResidue:179844] O4'-phospho-L-tyrosine at 1172 [ModifiedResidue:179872] O4'-phospho-L-tyrosine at 1197 [ModifiedResidue:180321] O4'-phospho-L-tyrosine at 1016
inDisease	true
maxDepth	1
modified	[InstanceEdit:9831583] Orlic-Milacic, Marija, 2023-03-22
name	p-6Y-EGFR K739_I744dup Phosphorylated Epidermal Growth Factor Receptor K739_I744dup p-6Y-EGFR Lys739_Ile744dup
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1996346
startCoordinate	25
updateTrackers	[UpdateTracker:9905410] Update Tracker - [EntityWithAccessionedSequence:1996346] p-6Y-EGFR K739_I744dup [plasma membrane] - v85:[modifyName] [UpdateTracker:9887581] Update Tracker - [EntityWithAccessionedSequence:1996346] p-6Y-EGFR K739_I744dup [plasma membrane] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905410] Update Tracker - [EntityWithAccessionedSequence:1996346] p-6Y-EGFR K739_I744dup [plasma membrane] - v85:[modifyName] [UpdateTracker:9887581] Update Tracker - [EntityWithAccessionedSequence:1996346] p-6Y-EGFR K739_I744dup [plasma membrane] - v46:[modifyName]
(hasCandidate)	[CandidateSet:R-HSA-1182982] Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane]

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