CD40L binds CD40

Stable Identifier
R-HSA-199404
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CD40L binds CD40
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CD40 is a member of the Tumour Necrosis Factor receptor family and its ligand CD40L is a type II transmembrane protein of the TNF superfamily. The latter is expressed preferentially on T-cells and platelets. In the immune system, CD40-CD40L interaction affects some key processes such as immune cell activation, differentiation, proliferation, and apoptosis. CD40-CD40L interaction also upregulates costimulatory molecules (ICAM-1, VCAM-1, E-selectin, LFA-3, B7.1, B7.2, class II MHC, and CD40 itself).
Literature References
PubMed ID Title Journal Year
16893496 CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system

Wang, JM, Chen, K, Zhang, L, Yu, P, Huang, J, Gong, W

Cell Mol Immunol 2006
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Orthologous Events
CD40L binds CD40 (Bos taurus)
CD40L binds CD40 (Canis familiaris)
CD40L binds CD40 (Danio rerio)
CD40L binds CD40 (Gallus gallus)
CD40L binds CD40 (Mus musculus)
CD40L binds CD40 (Rattus norvegicus)
CD40L binds CD40 (Sus scrofa)
CD40L binds CD40 (Xenopus tropicalis)
Authored
de Bono, B  (2007-07-08)
Reviewed
Barrow, AD  (2015-05-13)
Trowsdale, J  (2007-08-06)
Created
de Bono, B  (2007-07-10)
Cite Us!