Reactome | p38MAPK phosphorylates MSK1

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p38MAPK phosphorylates MSK1 Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:198647] protein serine/threonine kinase activity of p-p38 MAPK alpha/beta [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:198702] 2007-07-10 08:01:56
dbId	198669
displayName	p38MAPK phosphorylates MSK1
eventOf	[Pathway:R-HSA-198753] ERK/MAPK targets - Homo sapiens
followingEvent	[Reaction:R-HSA-199910] MSK1 activates ATF1 - Homo sapiens [Reaction:R-HSA-199935] MSK1 activates CREB - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-198657] RPS6KA5 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199367] Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	p38MAPK phosphorylates MSK1
orthologousEvent	[Reaction:R-SCE-198669] p38MAPK phosphorylates MSK1 - Saccharomyces cerevisiae [Reaction:R-SPO-198669] p38MAPK phosphorylates MSK1 - Schizosaccharomyces pombe [Reaction:R-DDI-198669] p38MAPK phosphorylates MSK1 - Dictyostelium discoideum [Reaction:R-CEL-198669] p38MAPK phosphorylates MSK1 - Caenorhabditis elegans [Reaction:R-DME-198669] p38MAPK phosphorylates MSK1 - Drosophila melanogaster [Reaction:R-GGA-198669] p38MAPK phosphorylates MSK1 - Gallus gallus [Reaction:R-DRE-198669] p38MAPK phosphorylates MSK1 - Danio rerio [Reaction:R-SSC-198669] p38MAPK phosphorylates MSK1 - Sus scrofa [Reaction:R-BTA-198669] p38MAPK phosphorylates MSK1 - Bos taurus [Reaction:R-CFA-198669] p38MAPK phosphorylates MSK1 - Canis familiaris [Reaction:R-RNO-198669] p38MAPK phosphorylates MSK1 - Rattus norvegicus [Reaction:R-MMU-198669] p38MAPK phosphorylates MSK1 - Mus musculus
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-198683] p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-198669
summation	[Summation:198692] MSK1 (Ribosomal protein S6 kinase alpha-5) is a serine/threo...

Referrals

(precedingEvent)	[Reaction:R-HSA-199910] MSK1 activates ATF1 [Reaction:R-HSA-199935] MSK1 activates CREB
(hasEvent)	[Pathway:R-HSA-198753] ERK/MAPK targets