Reactome | IRS1,2 [cytosol]

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IRS1,2 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-2671846] LEP:p-LEPR:p-JAK2:SH2B1:IRS1,2 [plasma membrane] - Homo sapiens [Complex:R-HSA-2671846] LEP:p-LEPR:p-JAK2:SH2B1:IRS1,2 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2671873] Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 - Homo sapiens [Reaction:R-HSA-2671873] Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 - Homo sapiens [Reaction:R-HSA-1168423] JAK2 phosphorylation of IRS-1/2 - Homo sapiens [Reaction:R-HSA-198211] Active TRKA binds IRS1/2 - Homo sapiens [BlackBoxEvent:R-HSA-8983003] IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 - Homo sapiens [Reaction:R-HSA-74707] Binding of IRS to insulin receptor - Homo sapiens
created	[InstanceEdit:198310] 2007-07-10 08:01:55
dbId	198273
deleted	[Deleted:9676736] Deletion of instance: 74698
displayName	IRS1,2 [cytosol]
hasMember	[EntityWithAccessionedSequence:R-HSA-57528] IRS2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-74769] IRS1 [cytosol] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-198273] IRS1,2 [cytosol] - Mus musculus [DefinedSet:R-RNO-198273] IRS1,2 [cytosol] - Rattus norvegicus [DefinedSet:R-CFA-198273] IRS1,2 [cytosol] - Canis familiaris [DefinedSet:R-BTA-198273] IRS1,2 [cytosol] - Bos taurus [DefinedSet:R-SSC-198273] IRS1,2 [cytosol] - Sus scrofa [DefinedSet:R-DRE-198273] IRS1,2 [cytosol] - Danio rerio [DefinedSet:R-XTR-198273] IRS1,2 [cytosol] - Xenopus tropicalis [DefinedSet:R-GGA-198273] IRS1,2 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-57528] chico [cytosol] - Drosophila melanogaster
maxDepth	2
modified	[InstanceEdit:5624358] Jupe, Steve, 2014-09-26
name	IRS1,2
producedByEvent	[Reaction:R-HSA-74747] Dephosphorylation of p-Y-IRS1,p-Y-IRS2 - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-198273
summation	[Summation:77422] The proteins mentioned here are examples of IRS family membe...
updateTrackers	[UpdateTracker:9870477] Update Tracker - [DefinedSet:198273] IRS1,2 [cytosol] - v38:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9870477] Update Tracker - [DefinedSet:198273] IRS1,2 [cytosol] - v38:[modifyName]
(replacementInstances)	[Deleted:9676736] Deletion of instance: 74698
(hasComponent)	[Complex:R-HSA-2671846] LEP:p-LEPR:p-JAK2:SH2B1:IRS1,2 [plasma membrane] [Complex:R-HSA-8982992] IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] [Complex:R-HSA-74699] IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] [Complex:R-HSA-198307] Activated TrkA receptor:IRS1/2 [plasma membrane]
(input)	[Reaction:R-HSA-2671873] Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 [BlackBoxEvent:R-HSA-8983003] IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 [Reaction:R-HSA-1168423] JAK2 phosphorylation of IRS-1/2 [Reaction:R-HSA-74707] Binding of IRS to insulin receptor [Reaction:R-HSA-198211] Active TRKA binds IRS1/2
(output)	[Reaction:R-HSA-74747] Dephosphorylation of p-Y-IRS1,p-Y-IRS2

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